Chronic clomipramine increases firing rate in lateral septal nuclei of the rat


Por: Contreras C.M., Marván Ma.L., Alcalá-Herrera V., Guzmán-Sáenz M.A.

Publicada: 1 ene 1990
Resumen:
A single dosage of several antidepressants produces an increased rate of firing in lateral septal nuclei of the rat. The objective of the present study was to clarify the long-term treatment action of clomipramine on the septal nuclei of the rat. A progressive increase of firing rate appeared after long-term treatment with clomipramine (1.25 mg/kg, IP; twice a day, for 25 days). The most noticeable firing increase occurred in the lateral septal nuclei, which primarily receive serotonergic innervation. Irregular changes occurred in the corpus callosum and cingulum. Finally, in other poorly innervated serotonergic septal regions, the treatment lacked effects. This suggested that the action of clomipramine was primarily due to interaction with the serotonergic system. © 1990.

Filiaciones:
Contreras C.M.:
 Depto. de Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico

 Laboratorio de Neurofarmacología, Centro de Investigaciones Biológicas Unversidad Veracruzana, Mexico

Marván Ma.L.:
 Depto. de Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico

 Laboratorio de Neurofarmacología, Centro de Investigaciones Biológicas Unversidad Veracruzana, Mexico

Alcalá-Herrera V.:
 Depto. de Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico

 Laboratorio de Neurofarmacología, Centro de Investigaciones Biológicas Unversidad Veracruzana, Mexico

Guzmán-Sáenz M.A.:
 Depto. de Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico

 Laboratorio de Neurofarmacología, Centro de Investigaciones Biológicas Unversidad Veracruzana, Mexico
ISSN: 00319384
Editorial
Elsevier Inc., THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND, Estados Unidos America
Tipo de documento: Article
Volumen: 48 Número: 4
Páginas: 551-554
WOS Id: A1990EF70400010
ID de PubMed: 2075206