Chronic clomipramine increases firing rate in lateral septal nuclei of the rat
Por:
Contreras C.M., Marván Ma.L., Alcalá-Herrera V., Guzmán-Sáenz M.A.
Publicada:
1 ene 1990
Resumen:
A single dosage of several antidepressants produces an increased rate of firing in lateral septal nuclei of the rat. The objective of the present study was to clarify the long-term treatment action of clomipramine on the septal nuclei of the rat. A progressive increase of firing rate appeared after long-term treatment with clomipramine (1.25 mg/kg, IP; twice a day, for 25 days). The most noticeable firing increase occurred in the lateral septal nuclei, which primarily receive serotonergic innervation. Irregular changes occurred in the corpus callosum and cingulum. Finally, in other poorly innervated serotonergic septal regions, the treatment lacked effects. This suggested that the action of clomipramine was primarily due to interaction with the serotonergic system. © 1990.
Filiaciones:
Contreras C.M.:
Depto. de Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Laboratorio de Neurofarmacología, Centro de Investigaciones Biológicas Unversidad Veracruzana, Mexico
Marván Ma.L.:
Depto. de Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Laboratorio de Neurofarmacología, Centro de Investigaciones Biológicas Unversidad Veracruzana, Mexico
Alcalá-Herrera V.:
Depto. de Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Laboratorio de Neurofarmacología, Centro de Investigaciones Biológicas Unversidad Veracruzana, Mexico
Guzmán-Sáenz M.A.:
Depto. de Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Laboratorio de Neurofarmacología, Centro de Investigaciones Biológicas Unversidad Veracruzana, Mexico
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