Biotin deficiency in protein-energy malnutrition
Por:
Velazquez A., Martin-del-Campo C., Baez A., Zamudio S., Quiterio M., Aguilar J.L., Perez-Ortiz B., Sanchez-Ardines M., Guzman-Hernandez J., Casanueva E.
Publicada:
1 ene 1989
Resumen:
Several of the clinical and biochemical manifestations of biotin deficiency also occur in severe protein-energy malnutrition (PEM). Average plasma biotin concentrations were lower in 16 malnourished children (10 with marasmus, 3 with kwashiorkor and 3 with marasmic kwashiorkor) than in 31 controls. Lymphocyte mitochondrial carboxylase activities were studied in 11 controls and in 10 patients with PEM; on the average, they were lower in the patients. Their activation indices (the ration of enzyme activity in cells incubated with biotin to activity in cells incubated without the vitamin) were higher in PEM. All these differences were statistically significant. None of these parameters were age-dependent in a range between 3 and 72 months. Carboxylase activities and plasma biotin levels increased to normal during nutritional recovery in two malnourished patients who were further studied. These results suggest that there is biotin deficiency in severe PEM. Urinary biotin concentrations, expressed per g of creatinine, were higher in the patients than in the controls; this may have been caused by increased renal clearance or by the reduced creatinine excretion which occurs in malnourished individuals. It will be important in future studies to determine the relative contribution of biotin deficiency to the malnourished phenotype.
Filiaciones:
Velazquez A.:
Unidad de Genetica de la Nutricion, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico
Martin-del-Campo C.:
Unidad de Genetica de la Nutricion, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico
Baez A.:
Unidad de Genetica de la Nutricion, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico
Zamudio S.:
Unidad de Genetica de la Nutricion, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico
Quiterio M.:
Unidad de Genetica de la Nutricion, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico
Aguilar J.L.:
Unidad de Genetica de la Nutricion, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico
Perez-Ortiz B.:
Unidad de Genetica de la Nutricion, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico
Sanchez-Ardines M.:
Unidad de Genetica de la Nutricion, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico
Guzman-Hernandez J.:
Unidad de Genetica de la Nutricion, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico
Casanueva E.:
Unidad de Genetica de la Nutricion, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico
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