The connective tissue diseases as disorders of immune regulation
Por:
Alarcon-Segovia D., Alcocer-Varela J., Diaz-Jouanen E.
Publicada:
1 ene 1985
Resumen:
The theory behind all of this chapter is that in each of the connective tissue diseases the immunoregulatory disturbances are different and thus they reach autoimmunity by a different pathway. The resulting autoantibodies may modulate further the dysregulation and may influence or determine the clinical manifestations of each disease. In some instances, such as seems to be the case in scleroderma, the interactions between the immune system and other tissues (e.g. fibroblasts) may determine the characteristics of the disease. In other instances, like in RA, the compartmentalization of the process may determine the site of primary involvement (e.g. the joints). Further investigation of the dysregulation in each of the connective tissue diseases may help their understanding. Further avenues of treatment may be explored, including ad hoc correction or modulation of the aberrant biological functions.
Filiaciones:
Alarcon-Segovia D.:
Department of Rheumatology and Immunology, Faculty of Medicine, Universidad Nacional Autonoma de Mexico, 14000 Mexico DF, Mexico
Alcocer-Varela J.:
Department of Rheumatology and Immunology, Faculty of Medicine, Universidad Nacional Autonoma de Mexico, 14000 Mexico DF, Mexico
Diaz-Jouanen E.:
Department of Rheumatology and Immunology, Faculty of Medicine, Universidad Nacional Autonoma de Mexico, 14000 Mexico DF, Mexico
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