Does interferon exert its actions through opiate receptors
Por:
Reyes-Vazquez C., Weisbrodt N., Dafny N.
Publicada:
1 ene 1984
Resumen:
It had been reported that alpha interferom (?-IFN) induces endorphin-like effects such as analgesia and catatonia. These effects, reversed and prevented by naloxone, suggest that the ?-IFN effect is mediated via opiate receptors. In order to examine this hypothesis, the present study was initiated. Extracellular cortical cell recording and microiontophoretic application of ?-IFN, morphine, and naloxone, as well as the application of these three drugs on the coaxially stimulated guinea-pig ileum preparation were used. ?-IFN application induced excitation in cortical cells and on the guinea-pig ileum. In contrast, the main effect elicited by morphine was a decrease in both preparations. Naloxone was able to reverse and/or prevent the morphine effects in both preparations, but failed to alter the effects induced by ?-IFN. The present observations using the guinea-pig ileum preparation and cortical neurons recording failed to support the hypothesis that ?-IFN effects are mediated via opiate receptors. © 1984.
Filiaciones:
Reyes-Vazquez C.:
Departamento de Fisiologia, Facultad de Medicina, U.N.A.M., Apdo Postal 70-250, Mexico 04510 D.F., USA
Weisbrodt N.:
Department of Physiology, The University of Texas Medical School, Houston, TX 77025, United States
Dafny N.:
Department of Neurobiology, The University of Texas Medical School, Houston, TX 77025, United States
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