Alteration of morphine withdrawal to naloxone by interferon
Por:
Dafny N., Zielinksi M., Reyes-Vazquez C.
Publicada:
1 ene 1983
Resumen:
The opiate abstinence syndrome represents a fundamental feature of the addictive process. The present study demonstrated that: 1) recombinant leukocyte A Interferon (?-IFN) injection prior to chronic morphine treatment reduces addiction liability; and 2) ?-IFN and not human ?-IFN injection to morphine dependent rats significantly modifies the naloxone-induced abstinence syndrome in a characteristic dose response manner. Two hypotheses concerning IFN's action were discussed. © 1983.
Filiaciones:
Dafny N.:
Department of Neurobiology, Anatomy The University, Texas Medical School at Houston, P.O. Box 20708, Houston, TX 77025, United States
Zielinksi M.:
Department of Neurobiology, Anatomy The University, Texas Medical School at Houston, P.O. Box 20708, Houston, TX 77025, United States
Reyes-Vazquez C.:
Departamento de Fisiologia, Facultad de Medicina, U.N.A.M., Apdo, Postal 70250, Mexico, 04510 D.F., Mexico
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