Independent changes in cerebrospinal fluid and in blood pH and lactate concentrations in children with purulent meningitis
Por:
Vargas Origel A., Abrego Morales R., Martinez M.C., Jasso Gutierrez L.
Publicada:
1 ene 1983
Resumen:
In order to evaluate the relationship of the hydrogen and lactate concentrations in cerebrospinal fluid (CSF) with those in the blood, three groups of children were studied: Group I, (n = 20) with purulent meningitis (PM); Group II, (n = 20) with metabolic acidosis and Group III, (n = 17) with suspicion of septicemia but no metabolic acidosis. In all infants a CSF sample was obtained for cytochemical analysis, culture as well as pH and lactate determinations; the latter two were also measured in a blood sample obtained simultaneously. In group I, the CSF [H+] and [lactate] were higher than in the blood (p < 0.001 and < 0.01 respectively) and no significant correlation was observed between the CSF and blood values. In group II, no such differences existed in [H+] and [lactate] between both compartments and again no correlation was disclosed between CSF and blood values. In group III only the [H+] was higher in CSF than in blood (p < 0.01) and a significant correlation was observed between both compartments (r = 0.486, p < 0.05). The existence of differences in group I among the CSF and blood [H+] and [lactate], along with the lack of correlation between CSF and blood [H+] or [lactate], could suggest that such compartmental changes are independent from each other. However, the variations were quite large and thus, the biological significance of this observation could be questioned.
Filiaciones:
Vargas Origel A.:
Dep. Neuronatol., Hosp. Pediatr., Cent. Med. Nac., Inst. Mex. Seguro Soc., Mexico 7 DF, Mexico
Abrego Morales R.:
Dep. Neuronatol., Hosp. Pediatr., Cent. Med. Nac., Inst. Mex. Seguro Soc., Mexico 7 DF, Mexico
Martinez M.C.:
Dep. Neuronatol., Hosp. Pediatr., Cent. Med. Nac., Inst. Mex. Seguro Soc., Mexico 7 DF, Mexico
Jasso Gutierrez L.:
Dep. Neuronatol., Hosp. Pediatr., Cent. Med. Nac., Inst. Mex. Seguro Soc., Mexico 7 DF, Mexico
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