Frequency and types of induced and spontaneous chromosome aberrations in relation to cell kinetics
Por:
Mutchinick O., Ruz L., Gonsebatt M.E., Mauleón P., Lisker R., García G.
Publicada:
1 ene 1981
Resumen:
Induced and spontaneous structural chromosome aberrations (SCA) were studied in a child accidentally radiated with a high dose of 192Ir, and in three sibs with Fanconi's anemia, analyzing by separate first division metaphases (FDM) and second division metaphases (SDM). The results showed that the number of SCA, number of cells with aberrations, and SCA per cell were markedly higher in FDM in all patients.Furthermore, for some type of structural changes like dicentric chromosomes and chromatid interchanges, the differences were particularly striking. The importance of ascertaining FDM identified with proper techniques, for the study of the clastogenic effect of environmental agents and some aspects related to the differences in cytogenetic features found in diverse tissues in Fanconi's anemia are discussed. © 1981 Springer-Verlag.
Filiaciones:
Mutchinick O.:
Departamento de Genética, Instituto Nacional de la Nutrición Salvador Zubirán, San Fernando y Viaducto Tlalpan, México 22, D.F., Mexico
Ruz L.:
Departamento de Genética, Instituto Nacional de la Nutrición Salvador Zubirán, San Fernando y Viaducto Tlalpan, México 22, D.F., Mexico
Gonsebatt M.E.:
Departamento de Genética, Instituto Nacional de la Nutrición Salvador Zubirán, San Fernando y Viaducto Tlalpan, México 22, D.F., Mexico
Mauleón P.:
Departamento de Genética, Instituto Nacional de la Nutrición Salvador Zubirán, San Fernando y Viaducto Tlalpan, México 22, D.F., Mexico
Lisker R.:
Departamento de Genética, Instituto Nacional de la Nutrición Salvador Zubirán, San Fernando y Viaducto Tlalpan, México 22, D.F., Mexico
García G.:
Servicio de Pediatria, Hospital M. Gea González, México, Mexico
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