Bactericidal capacity of newborn phagocytes against group B beta-hemolytic streptococci
Por:
Becker I.D., Robinson O.M., Bázan T.S., López-Osuna M., Kretschmeri R.R.
Publicada:
1 ene 1981
Resumen:
The bactericidal capacity of mononuclear and polymorphonuclear phagocytes obtained from normal newborn infants and from healthy adults was evaluated in vitro, using two group B beta-hemolytic streptococci (GBBHS) serotypes (GBBHS-Ia-SS-615/28 and GBBHS-III-SS-620/50) and uniform opsonic conditions. No intertype differences in bacteriolysis of these two serotypes were observed among leukocytes from newborns or adults. As a group, only polymorphonuclear phagocytes from newborns disclosed a significantly lower mean bactericidal capacity than their adult cellular counterpart, and only with respect to GBBHS-III-SS-620/50. On the other hand, 4 of 16 polymorphonuclear samples from newborns tested revealed significantly low bactericidal capacities against both GBBHS serotypes, and an additional sample revealed a bactericidal capacity against GBBHS-III-SS-620/50 alone. Interstrain variations in the intrinsic bactericidal capacity of polymorphonuclear phagocytes from newborns against GBBHS-III may exist, as suggested by a single observation made by using four clinical isolates of GBBHS-III. Such deviant phagocytic capacities of polymorphonuclear phagocytes from newborns may constitute an additional selective risk factor in the genesis of GBBHS sepsis of the newborn.
Filiaciones:
Becker I.D.:
Division of Immunology, Subjefatura de Investigacion Cientifica, Mexico
National Institutes of Health, Building 10, Bethesda, MD 20205, United States
Robinson O.M.:
Division of Immunology, Subjefatura de Investigacion Cientifica, Mexico
Instituto de Investigaciones Biomedicas, U.N.A.M., México, D.F., Mexico
Bázan T.S.:
Division of Immunology, Subjefatura de Investigacion Cientifica, Mexico
Hospital de Gineco-Obstetricia II, Centro Medico Nacional, I.M.S.S., Mexico
López-Osuna M.:
Division of Immunology, Subjefatura de Investigacion Cientifica, Mexico
Kretschmeri R.R.:
Division of Immunology, Subjefatura de Investigacion Cientifica, Mexico
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