Facilitation of conditioned motor suppression by microinjections of dopamine in the caudate nucleus of cats
Por:
Zarco-Coronado I., Reyes-Vázquez C., Brust-Carmona H.
Publicada:
1 ene 1979
Resumen:
The effects of Caudate Nucleus (CN) injections of catecholamines on the suppression of a motor conditioned response (MCR), lever pressing, was investigated. Cats were trained to press a lever to obtain 0.5 ml of milk when a conditioned discriminative stimulus was on (CS-on-reward on, MCR) and to suppress the response when the light was off (CS-off-reward off, suppression of motor conditioned response, SMCR). The bilateral application of 5 or 10 ?g of Dopamine (DA) through chronically implanted cannulae in the CN significantly decreased the lever pressing in the non rewarding situation without changing the MCR. Injections of 5 ?g of L-DOPA caused very small effects assessed during the following 10 min. However, 10 ?g of L-DOPA produced a significant decrement of lever pressing (CS-off) in two out of four injections. These findings further support the postulation that catecholamines in the CN have a behavioral inhibitory action upon a motor conditioned response. © 1979.
Filiaciones:
Zarco-Coronado I.:
Depto. de Fisiología, Div. de Investigación, Facultad de Medicina Universidad Nacional Autónoma de México México, D.F. Apartado Postal, 70250
Reyes-Vázquez C.:
Depto. de Fisiología, Div. de Investigación, Facultad de Medicina Universidad Nacional Autónoma de México México, D.F. Apartado Postal, 70250
Brust-Carmona H.:
Depto. de Fisiología, Div. de Investigación, Facultad de Medicina Universidad Nacional Autónoma de México México, D.F. Apartado Postal, 70250
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