Thermic cutaneous pain threshold in humans: modifications produced by pirazolone [UMBRAL AL DOLOR TERMICO CUTANEO EN EL HOMBRE: MODIFICACIONES PRODUCIDAS POR LA PIRAZOLONA]


Por: Fernandez Guardiola A., Ostrosky F., Condes M.

Publicada: 1 ene 1974
Resumen:
A method for measuring pain threshold in humans is described, employing the thermal cutaneous technique of Hardy et al. In the pirazolone test trials, neomelubrine in 500 and 1,000 mg doses, as well as a placebo, was administered orally in a double blind randomized fashion. Each variable (subjective pain threshold, alpha rhythm blockage duration and galvanic skin response, i.e. GSR) was independently analyzed and later was correlated by means of a formula which establishes a relationship between pain threshold and pain response. The pirazolones diminished the alpha rhythm blockade duration average and the GSR amplitude average. The substances also reduced the thermic cutaneous pain threshold. The usefulness of the method employed, and the possible central nervous system effect of pirazolone are discussed.

Filiaciones:
Fernandez Guardiola A.:
 Unidad Invest. Cerebr., Inst. Nac. Neurol., SSA, Mexico City, Mexico

Ostrosky F.:
 Unidad Invest. Cerebr., Inst. Nac. Neurol., SSA, Mexico City, Mexico

Condes M.:
 Unidad Invest. Cerebr., Inst. Nac. Neurol., SSA, Mexico City, Mexico
ISSN: 00257729
Tipo de documento: Article
Volumen: 54 Número: 1185
Páginas: 367-374

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