Seizure inhibition and REM sleep: A possible neurohumoral relationship


Por: Drucker-Colin R.R.

Publicada: 1 ene 1974
Resumen:
Several studies have shown a relationship between certain aspects of seizures and REM sleep. This study attempts to further investigate this. Cats were randomly assigned to being donors or recipients. Donors had a bilateral push-pull chemitrode system implanted in the ventral hippocampus, while recipients had push-pull cannulae implanted in the Midbrain Reticular Formation. Threshold after-discharges were obtained from the hippocampus of donor cats, and perfusates were obtained from the contralateral hippocampus during the post-ictal depression period. Such perfusates were then reperfused into the MRF of recipient cats and SWS and REM latencies were obtained and compared to controls. In addition, NE, 5-HT, Ach, and GABA were perfused in the hippocampus while the contralateral hippocampus was stimulated to induce after-discharges. These same substances were then perfused into the MRF in order to determine their effects on sleep latencies. Results showed that the post-ictal perfusate significantly reduced REM latencies when compared to all other perfusion tests, while only 5-HT and GABA inhibited after-discharges. These results are discussed in terms of the relationship between seizures and REM and with some aspects of their ontogeny and phylogeny. © 1974 Academic Press, Inc.

Filiaciones:
Drucker-Colin R.R.:
 Department of Psychobiology, University of California, Irvine, CA 92664, United States
ISSN: 00916773
Tipo de documento: Article
Volumen: 12 Número: 2
Páginas: 199-209
WOS Id: A1974U442900004
ID de PubMed: 4154738