Antagonism of tremorine-induced tremor by serotoninergic agents in mice. Interactions with levodopa.
Por:
Rodríguez R.
Publicada:
1 ene 1972
Resumen:
The serotonin precursor 5-hydroxytryptophan and the serotonin-like agent quipazine (2-(1-piperazinyl)quinoline), were found to antagonize tremorine-induced tremor in mice. Coadministration of quipazine and levodopa resulted in potentiation of the latter's antitremorine effect. 5-Hydroxytryptophan increased levodopa activity when administered before, but not simultaneously with the dopamine precursor. These data suggest that serotoninergic drugs may be useful in the treatment of Parkinson's disease and support the possibility of a relationship between serotonin deficiency and this disorder. © 1972.
Filiaciones:
Rodríguez R.:
Instituto Miles de Terapéutica Experimental, Apartado Postal 22026, México 22, D.F., Mexico
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