Different Association of Human Papillomavirus 16 Variants with Early and Late Presentation of Cervical Cancer
Por:
Alfaro, Ana, Juarez-Torres, Eligia, Medina-Martinez, Ingrid, Mateos-Guerrero, Norma, Bautista-Huerta, Maura, Roman-Bassaure, Edgar, Villegas-Sepulveda, Nicolas, Berumen, Jaime
Publicada:
30 dic 2016
Resumen:
The median age of cervical cancer (CC) presentation coincides with the
mean age of menopause presentation (49 years) in Mexico. Here, we
investigated the association between different HPV16 variants and early
(<= 49 years) or delayed (>= 50 years) CC presentation. We conducted a
case-case study that included 462 CCs, 386 squamous cell carcinomas
(SCC), 63 adenocarcinomas (ACC), and 13 additional cell types. Variants
were identified by PCR and DNA sequencing. The risk conferred by each
variant for developing CC earlier than 50 years was analyzed using a
univariate logistic regression model considering old aged patients (>=
50 years) and non-HPV16 cases as the reference variables. Overall, the
frequency of HPV16 was 50.9%, and the only identified variants were the
European A1/2 (31.2%) and the Asian-American D2 (10.8%), and D3
(8.9%). D2 was mainly associated with <= 49-year-old patients (15.9%);
A1/2 was uniformly distributed between the two age groups (similar to
31%), whereas D3 increased with age to a frequency of 11.8% in the
older group. Only the D2 variant conferred a 3.3-fold increase in the
risk of developing CC before 50 years of age (OR = 3.3, 95% Cl =
1.7-6.6, p < 0.001) in relation with non-HPV16 cases. Remarkably, this
risk was higher for ACC (OR = 6.0, 95% CI = 1.1-33, p < 0.05) than for
SCC (OR = 2.8, 95% Cl = 1.3-5.9, p < 0.01). Interestingly, when
analyzing only the HPV16-positive CC, D2 increases (OR = 2.5, 95% CI =
1.2-5, p < 0.05) and D3 decreases (OR = 0.45, 95% CI 0.2-0.9, p < 0.05)
the risk to develop CC before 50 years old in relation with A1/2
variant. These results indicated that D2 variant is associated with
early and D3 with delayed CC presentation, whereas A1/2 variant was
uniformly distributed between the two age groups.
Filiaciones:
Alfaro, Ana:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Unidad Med Genom, Mexico City, DF, Mexico
Juarez-Torres, Eligia:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Unidad Med Genom, Mexico City, DF, Mexico
Medina-Martinez, Ingrid:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Unidad Med Genom, Mexico City, DF, Mexico
Mateos-Guerrero, Norma:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Unidad Med Genom, Mexico City, DF, Mexico
Bautista-Huerta, Maura:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Unidad Med Genom, Mexico City, DF, Mexico
Roman-Bassaure, Edgar:
Hosp Gen Mexico City, Serv Oncol, Mexico City, DF, Mexico
Villegas-Sepulveda, Nicolas:
Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Biomed Mol, Mexico City, DF, Mexico
Berumen, Jaime:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Unidad Med Genom, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Med Expt, Mexico City, DF, Mexico
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