Helminth-induced Ly6Chi monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis
Por:
Terrazas, Cesar, Ruiz-Rosado, Juan de Dios, Amici, Stephanie A., Jablonski, Kyle A., Martinez-Saucedo, Diana, Webb, Lindsay M., Cortado, Hanna, Robledo-Avila, Frank, Oghumu, Steve, Satoskar, Abhay R., Rodriguez-Sosa, Miriam, Terrazas, Luis I., Guerau-de-Arellano, Mireia, Partida-Sanchez, Santiago
Publicada:
17 ene 2017
Categoría:
Multidisciplinary
Resumen:
Helminths cause chronic infections and affect the immune response to unrelated inflammatory diseases. Although helminths have been used therapeutically to ameliorate inflammatory conditions, their anti-inflammatory properties are poorly understood. Alternatively activated macrophages (AAMfs) have been suggested as the anti-inflammatory effector cells during helminth infections. Here, we define the origin of AAMfs during infection with Taenia crassiceps, and their disease-modulating activity on the Experimental Autoimmune Encephalomyelitis (EAE). Our data show two distinct populations of AAMfs, based on the expression of PD-L1 and PD-L2 molecules, resulting upon T. crassiceps infection. Adoptive transfer of Ly6C+ monocytes gave rise to PD-L1+/PD-L2+, but not PD-L1+/PD-L2- cells in T. crassiceps-infected mice, demonstrating that the PD-L1+/PD-L2+ subpopulation of AAMfs originates from blood monocytes. Furthermore, adoptive transfer of PD-L1+/PD-L2+ AAMfs into EAE induced mice reduced disease incidence, delayed disease onset, and diminished the clinical disability, indicating the critical role of these cells in the regulation of autoimmune disorders. © The Author(s) 2017.
Filiaciones:
Terrazas, Cesar:
Ohio State Univ, Dept Pathol, Columbus, OH 43221 USA
Ruiz-Rosado, Juan de Dios:
Nationwide Childrens Hosp, Res Inst, Ctr Microbial Pathogenesis, Columbus, OH 43205 USA
Amici, Stephanie A.:
Ohio State Univ, Sch Hlth & Rehabil Sci, Med Lab Sci Div, Columbus, OH 43210 USA
Jablonski, Kyle A.:
Ohio State Univ, Sch Hlth & Rehabil Sci, Med Lab Sci Div, Columbus, OH 43210 USA
Martinez-Saucedo, Diana:
UNAM, Fac Estudios Super Iztacala, Unidad Biomed, Tlalnepantla, Mex, Mexico
Webb, Lindsay M.:
Ohio State Univ, Sch Hlth & Rehabil Sci, Med Lab Sci Div, Columbus, OH 43210 USA
Ohio State Univ, Biomed Sci Grad Program, Columbus, OH 43210 USA
Cortado, Hanna:
Nationwide Childrens Hosp, Res Inst, Ctr Microbial Pathogenesis, Columbus, OH 43205 USA
Robledo-Avila, Frank:
Nationwide Childrens Hosp, Res Inst, Ctr Microbial Pathogenesis, Columbus, OH 43205 USA
Oghumu, Steve:
Ohio State Univ, Coll Publ Hlth, Environm Hlth Sci, Columbus, OH 43210 USA
Satoskar, Abhay R.:
Ohio State Univ, Dept Pathol, Columbus, OH 43221 USA
Rodriguez-Sosa, Miriam:
UNAM, Fac Estudios Super Iztacala, Unidad Biomed, Tlalnepantla, Mex, Mexico
Terrazas, Luis I.:
UNAM, Fac Estudios Super Iztacala, Unidad Biomed, Tlalnepantla, Mex, Mexico
Guerau-de-Arellano, Mireia:
Ohio State Univ, Sch Hlth & Rehabil Sci, Med Lab Sci Div, Columbus, OH 43210 USA
Partida-Sanchez, Santiago:
Nationwide Childrens Hosp, Res Inst, Ctr Microbial Pathogenesis, Columbus, OH 43205 USA
Ohio State Univ, Coll Med, Dept Pediat, Columbus, OH 43210 USA
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