Lipopolysaccharide Binding Protein and Oxidative Stress in a Multiple Sclerosis Model
Por:
Escribano, Begoa M., Medina-Fernandez, Francisco J., Aguilar-Luque, Macarena, Aguera, Eduardo, Feijoo, Montserrat, Garcia-Maceira, Fe I., Lillo, Rafael, Vieyra-Reyes, Patricia, Giraldo, Ana I., Luque, Evelio, Drucker-Colin, Rene, Tunez, Isaac
Publicada:
1 ene 2017
Resumen:
Recent findings in experimental autoimmune encephalomyelitis (EAE)
suggest that altering certain bacterial populations present in the gut
may lead to a proinflammatory condition, that could result in the
development of multiple sclerosis (MS). Also, Reactive Oxygen Species
seem to be involved in the course of MS. In this study, it has been
aimed to relate all these variables starting from an analysis of the
lipopolysaccharide (LPS) and LPS-binding protein (LBP) with the
determination of parameters related to oxidative stress in the blood,
brain and spinal cord. For this purpose, samples obtained from EAE rats
and relapsing-remitting (RRMS) MS patients were used. In addition, EAE
rats were treated with Natalizumab, N-acetyl-cysteine and dimethyl
fumarate. Natalizumab was also employed in RRMS. The results of this
study revealed an improvement in the clinical symptoms of the EAE and MS
with the treatments, as well as a reduction in the oxidative stress
parameters and in LBP. Correlations between the clinical variables of
the disease, i.e. oxidative damage and LBP, were established. Although
the conclusions of this research are indeed relevant, further
investigation would be necessary to establish the intrinsic mechanisms
of the MS-oxidative stress-microbiota relationship.
Filiaciones:
Escribano, Begoa M.:
Univ Cordoba, Fac Vet, Dept Biol Celular Fisiol & Inmunol, Cordoba, Spain
IMIBIC, Cordoba, Spain
Medina-Fernandez, Francisco J.:
IMIBIC, Cordoba, Spain
Univ Cordoba, Fac Med, Dept Bioquim & Biol Mol, Cordoba, Spain
Aguilar-Luque, Macarena:
IMIBIC, Cordoba, Spain
Univ Cordoba, Fac Med, Dept Bioquim & Biol Mol, Cordoba, Spain
Aguera, Eduardo:
IMIBIC, Cordoba, Spain
Hosp Univ Reina Sofia Cordoba, Serv Neurol, Cordoba, Spain
Feijoo, Montserrat:
IMIBIC, Cordoba, Spain
Univ Cordoba, Fac Med, Dept Bioquim & Biol Mol, Cordoba, Spain
Garcia-Maceira, Fe I.:
Canvax Biotech SL, Parque Cient Rabanales 21, Cordoba, Spain
Lillo, Rafael:
IMIBIC, Cordoba, Spain
Univ Cordoba, Fac Med, Dept Ciencias Sociosanitarias & Radiol & Med Fis, Secc Psiquiatria, Cordoba, Spain
Vieyra-Reyes, Patricia:
Univ Autonoma Estado Mexico, Fac Med, Dept Neurofisiol Conducta, Toluca, Estado De Mexic, Mexico
Giraldo, Ana I.:
IMIBIC, Cordoba, Spain
Univ Cordoba, Fac Med, Dept Bioquim & Biol Mol, Cordoba, Spain
Luque, Evelio:
IMIBIC, Cordoba, Spain
Univ Cordoba, Fac Med, Dept Ciencias Morfol, Secc Histol, Cordoba, Spain
Drucker-Colin, Rene:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Neuropatol Mol, Mexico City, DF, Mexico
Tunez, Isaac:
IMIBIC, Cordoba, Spain
Univ Cordoba, Fac Med, Dept Bioquim & Biol Mol, Cordoba, Spain
Red Temat Invest Cooperat Envejecimiento & Fragil, Cordoba, Spain
|