Membrane progesterone receptors in reproduction and cancer
Por:
Valadez-Cosmes P., Ricardo Vazquez-Martinez, Edgar, Cerbón M., Camacho-Arroyo I.
Publicada:
15 oct 2016
Resumen:
Progesterone is a sexual steroid hormone that has a critical role in
reproductive processes in males and females of several species,
including humans. Furthermore, progesterone has been associated with
pathological diseases such as breast, gynecological and brain cancer,
regulating cell proliferation, apoptosis, and metastasis. In the past,
progesterone actions were thought to be only mediated by its
intracellular receptor (PR). However, recent evidence has demonstrated
that membrane progesterone receptors (mPRs) mediate most of the
non-classical progesterone actions. The role of the different mPRs
subtypes in progesterone effects in reproduction and cancer is an
emerging and exciting research area. Here we review studies to date
regarding mPRs role in reproduction and cancer and discuss their
functions and clinical relevance, suggesting mPRs as putative
pharmacological targets and disease markers in cancer and diseases
associated with reproduction. (C) 2016 Elsevier Ireland Ltd. All rights
reserved.
Filiaciones:
Valadez-Cosmes P.:
Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Cerbón M.:
Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Camacho-Arroyo I.:
Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
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