Future therapeutic targets for the treatment and prevention of cholesterol gallstones
Por:
Castro-Torres I.G., CardenasVazquez, RD, Velázquez-González C., Ventura-Martínez R., De La O-Arciniega M., Naranjo-Rodríguez E.B., Martínez-Vázquez M.
Publicada:
15 oct 2015
Categoría:
Pharmacology
Resumen:
The formation of cholesterol gallstones involves very complex imbalances, such as alterations in the secretion of biliary lipids (which involves the ABCG5, ABCG8, ABCB4 and ABCB11 transporters), biochemical and immunological reactions in the gallbladder that produce biliary sludge (mucins), physicochemical changes in the structure of cholesterol (crystallization), alterations in gallbladder motility, changes in the intestinal absorption of cholesterol (ABCG5/8 transporters and Niemann-Pick C1L1 protein) and alterations in small intestine motility. Some of these proteins have been studied at the clinical and experimental levels, but more research is required. In this review, we discuss the results of studies on some molecules involved in the pathophysiology of gallstones that may be future therapeutic targets to prevent the development of this disease, and possible sites for treatment based mainly on the absorption of intestinal cholesterol (Niemann-Pick C1L1 and ABCG5/8 proteins). © 2015 Published by Elsevier B.V.
Filiaciones:
Castro-Torres I.G.:
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
Instituto de Química, Universidad Nacional Autónoma de México, México, D.F., Mexico
CardenasVazquez, RD:
Univ Nacl Autonoma Mexico, Fac Ciencias, Dept Biol Celular, Mexico City 04510, DF, Mexico
Velázquez-González C.:
Área Académica de Farmacia, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca de Soto, Hidalgo, Mexico
Ventura-Martínez R.:
Univ Nacl Autonoma Mexico, Fac Med, Dept Farmacol, Mexico City 04510, DF, Mexico
Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F., Mexico
De La O-Arciniega M.:
Área Académica de Farmacia, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca de Soto, Hidalgo, Mexico
Naranjo-Rodríguez E.B.:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, México, D.F., Mexico
Martínez-Vázquez M.:
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
Instituto de Química, Universidad Nacional Autónoma de México, México, D.F., Mexico
Departamento de Biología Celular, Facultad de Ciencias, Universidad Nacional Autónoma de México, México, D.F., Mexico
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