A prospective follow-up of adipocytokines in cohort patients with gout: Association with metabolic syndrome but not with clinical inflammatory findings: Strobe-compliant article
Por:
García-Méndez S., Rivera-Bahena C.B., Montiel-Hernández J.L., Xibillé-Friedmann D., Álvarez-Hernández E., Peláez-Ballestas I., Burgos-Vargas R., Vázquez-Mellado J.
Publicada:
1 jul 2015
Categoría:
Medicine (miscellaneous)
Resumen:
The aim of this study was to determine the levels of leptin (Lep) and adiponectin (AdipoQ) in patients with gout and its relationship with joint inflammatory data and/or with metabolic syndrome (MetS) variables, during 1 year follow-up. Forty-one patients (40 males) with gout diagnosis, attending for the first time to a rheumatology department, were included. Evaluations were performed baseline, at 6 and 12 months. Variables included the following: demographic, clinical and laboratory data related to gout and associated diseases. Lep and AdipoQ determinations by the ELISA method were performed in frozen serum from each visit. The pharmacological and nopharmacological treatment for gout and associated diseases was individualized for each patient according to published guidelines. Statistical analysis includedMann-WhitneyUtest, Fisher test, x2,ANOVA,Cochran Q, Pearson and Spearman correlation tests, as well as linear regression. In the baseline evaluation, 29.2% had MetS (hypertriglyceridemia 66%, hypertension 44% and obesity 37%); patients with MetS had higher C reactive protein (CRP) levels [34.1±28.6 vs. 12.2±11.2mg/dL, P=0.033]. Although not significant, also had higher Lep and lower AdipoQ levels (3.2±3.0 vs. 1.9±1.2 ng/mL, P=0.142 and 40.5±26.8 vs. 38.0±24.9 ng/mL, P=0.877, respectively). During follow-up, our patients had significant improvement in serumuric acid (sUA) levels and variables evaluating pain and joint swelling (P = 0.05). Metabolic abnormalities tended to persist or even worsen during the monitoring period: significant increase in total cholesterol (P=0.004), tendency to higher triglycerides (P=0.883) and slight improvement in glycaemia (P=0.052). Lep values increased significantly during followup (P=0.001) while AdipoQ levels diminished slightly (P=0.317). Neither Lep nor AdipoQ values showed important correlation (r>0.5) with metabolic variables or joint swelling. This study suggests that in patients with gout, concentrations of Lep and Adipo Q are more in line with the metabolic state than with clinical disease activity. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
Filiaciones:
García-Méndez S.:
Servicio de Reumatología, Hospital General de México, Dr. Balmis 148, Col. Doctores, DF México, 06720, Mexico
Dirección de Planeación, Enseñanza e Investigación, Hospital Regional de Alta Especialidad de Oaxaca, San Bartolo Coyotepec, Oaxaca, Mexico
Rivera-Bahena C.B.:
Facultad de Farmacia, Universidad Autónoma Del Estado de Morelos, Mexico
Montiel-Hernández J.L.:
Facultad de Farmacia, Universidad Autónoma Del Estado de Morelos, Mexico
Xibillé-Friedmann D.:
Servicio de Reumatología, Hospital General de Cuernavaca Dr. José G. Parres, Cuernavaca, Morelos, Mexico
Álvarez-Hernández E.:
Servicio de Reumatología, Hospital General de México, Dr. Balmis 148, Col. Doctores, DF México, 06720, Mexico
Peláez-Ballestas I.:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
Servicio de Reumatología, Hospital General de México, Dr. Balmis 148, Col. Doctores, DF México, 06720, Mexico
Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
Burgos-Vargas R.:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
Servicio de Reumatología, Hospital General de México, Dr. Balmis 148, Col. Doctores, DF México, 06720, Mexico
Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
Vázquez-Mellado J.:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
Servicio de Reumatología, Hospital General de México, Dr. Balmis 148, Col. Doctores, DF México, 06720, Mexico
Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
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