Oxidative stress inhibition and oxidant activity by fibrous clays
Por:
Cervini-Silva J., Nieto-Camacho A., Gómez-Vidales V.
Publicada:
1 sep 2015
Resumen:
Fibrous clays (sepiolite, palygorskite) are produced at 1.2m tonnes per year and have a wide range of industrial applications needing to replace long-fibre length asbestos. However, information on the beneficial effects of fibrous clays on health remains scarce. This paper reports on the effect of sepiolite (Vallecas, Spain) and palygorskite (Torrejón El Rubio, Spain) on cell damage via oxidative stress (determined as the progress of lipid peroxidation, LP). The extent of LP was assessed using the Thiobarbituric Acid Reactive Substances assay. The oxidant activity by fibrous clays was quantified using Electron-Paramagnetic Resonance. Sepiolite and palygorskite inhibited LP, whereby corresponding IC50 values were 6557±1024 and 4250±289µgmL-1. As evidenced by dose-response experiments LP inhibition by palygorskite was surface-controlled. Fibrous clay surfaces did not stabilize HO species, except for suspensions containing 5000µgmL-1. A strong oxidant (or weak anti-oxidant) activity favours the inhibition of LP by fibrous clays. © 2015 Elsevier B.V.
Filiaciones:
Cervini-Silva J.:
Departamento de Procesos y Tecnología, Universidad Autónoma Metropolitana Unidad Cuajimalpa, México City, Mexico
Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, United States
Nieto-Camacho A.:
Univ Nacl Autonoma Mexico, Inst Quim, Lab Pruebas Biol, Mexico City 04510, DF, Mexico
Laboratorio de Pruebas Biológicas, Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria México City, Mexico
Gómez-Vidales V.:
Univ Nacl Autonoma Mexico, Inst Quim, Lab Resonancia Paramagnet Elect, Mexico City 04510, DF, Mexico
Laboratorio de Resonancia Paramagnética Electrónica, Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria México City, Mexico
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