Evaluating the functional state of adult-born neurons in the adult dentate gyrus of the hippocampus: from birth to functional integration
Por:
AguilarArredondo, A, Arias, C, Zepeda, A
Publicada:
1 jun 2015
Categoría:
Neuroscience (miscellaneous)
Resumen:
Hippocampal neurogenesis occurs in the adult brain in various species,
including humans. A compelling question that arose when neurogenesis was
accepted to occur in the adult dentate gyrus (DG) is whether new neurons
become functionally relevant over time, which is key for interpreting
their potential contributions to synaptic circuitry. The functional
state of adult-born neurons has been evaluated using various
methodological approaches, which have, in turn, yielded seemingly
conflicting results regarding the timing of maturation and functional
integration. Here, we review the contributions of different
methodological approaches to addressing the maturation process of
adult-born neurons and their functional state, discussing the
contributions and limitations of each method. We aim to provide a
framework for interpreting results based on the approaches currently
used in neuroscience for evaluating functional integration. As shown by
the experimental evidence, adult-born neurons are prone to respond from
early stages, even when they are not yet fully integrated into circuits.
The ongoing integration process for the newborn neurons is characterised
by different features. However, they may contribute differently to the
network depending on their maturation stage. When combined, the
strategies used to date convey a comprehensive view of the functional
development of newly born neurons while providing a framework for
approaching the critical time at which new neurons become functionally
integrated and influence brain function.
Filiaciones:
AguilarArredondo, A:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Arias, C:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Zepeda, A:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico
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