Immunomodulation and Anti-Inflammatory Effects of Garlic Compounds
Por:
Arreola R., Quintero-Fabián S., Lopez-Roa R.I., Flores-Gutierrez E.O., Reyes-Grajeda J.P., Carrera-Quintanar L., Ortuno-Sahagun D.
Publicada:
1 ene 2015
Resumen:
The benefits of garlic to health have been proclaimed for centuries;
however, only recently have Allium sativum and its derivatives been
proposed as promising candidates for maintaining the homeostasis of the
immune system. The complex biochemistry of garlic makes it possible for
variations in processing to yield different preparations with
differences in final composition and compound proportion. In this
review, we assess the most recent experimental results, which indicate
that garlic appears to enhance the functioning of the immune system by
stimulating certain cell types, such as macrophages, lymphocytes,
natural killer (NK) cells, dendritic cells, and eosinophils, by
mechanisms including modulation of cytokine secretion, immunoglobulin
production, phagocytosis, and macrophage activation. Finally, because
immune dysfunction plays an important role in the development and
progress of several diseases, we critically examined immunoregulation by
garlic extracts and compounds isolated, which can contribute to the
treatment and prevention of pathologies such as obesity, metabolic
syndrome, cardiovascular disorders, gastric ulcer, and even cancer. We
concluded that A. sativum modulates cytokine secretion and that such
modulation may provide a mechanism of action for many of their
therapeutic effects.
Filiaciones:
Arreola R.:
Psychiatric Genetics Department, National Institute of Psychiatry, Clinical Research Branch, Calzada Mexico-Xochimilco 101, Mexico City, 14370, Mexico
Quintero-Fabián S.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Inst Nacl Pediat, Unidad Genet Nutr, Mexico City 04530, DF, Mexico
Lopez-Roa R.I.:
Departamento de Farmacobiologia, CUCEI, Universidad de Guadalajara, Guadalajara, 44430, Mexico
Flores-Gutierrez E.O.:
National Institute of Psychiatry, Ramón de la Fuente, Clinical Research Branch, Calzada México-Xochimilco 101, Mexico City, 14370, Mexico
Reyes-Grajeda J.P.:
Instituto Nacional de Medicina Genomica, Periferico Sur No. 4809, Mexico, 14610, Mexico
Carrera-Quintanar L.:
Instituto de Investigacion en Ciencias Biomedicas, Universidad de Guadalajara, Sierra Mojada No. 950, Guadalajara, 44340, Mexico
Ortuno-Sahagun D.:
Instituto de Investigacion en Ciencias Biomedicas, Universidad de Guadalajara, Sierra Mojada No. 950, Guadalajara, 44340, Mexico
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