Reduced Systemic Levels of IL-10 Are Associated with the Severity of Obstructive Sleep Apnea and Insulin Resistance in Morbidly Obese Humans
Por:
Leon-Cabrera S., Arana-Lechuga Y., Esqueda-León E., Terán-Pérez G., Gonzalez-Chavez A., Escobedo G., Moctezuma, JV
Publicada:
1 ene 2015
Resumen:
Obstructive sleep apnea (OSA) has been related to elevation of
inflammatory cytokines and development of insulin resistance in morbidly
obese (MO) subjects. However, it is still unclear whether the systemic
concentration of anti-inflammatory mediators is also affected in MO
subjects directly related to the severity of OSA and level of insulin
resistance. Normal weight and MO subjects were subjected to overnight
polysomnography in order to establish the severity of OSA, according to
the apnea-hypopnea index (AHI). Blood samples were obtained for
estimation of total cholesterol and triglycerides, insulin, glucose,
insulin resistance, tumor necrosis factor alpha (TNF-alpha), interleukin
12 (IL12), and interleukin 10 (IL-10). Serum levels of IL-10 were
significantly lower in MO subjects with OSA than in MO and control
individuals without OSA. Besides being inversely associated with serum
TNF-alpha and IL-12, decreased IL-10 levels were significantly related
to increased AHI, hyperinsulinemia, and insulin resistance. Serum IL-10
is significantly reduced in morbidly obese subjects with severe OSA
while also showing a clear relationship with a state of hyperinsulinemia
and insulin resistance probably regardless of obesity in the present
sample. It may be of potential clinical interest to identify the
stimulatory mechanisms of IL-10 in obese individuals with OSA.
Filiaciones:
Leon-Cabrera S.:
Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Biomed, Tlalnepantla 54090, Mex, Mexico
Arana-Lechuga Y.:
Departamento de Biologia de la Reproduccion y Clinica de Trastornos de Sueno, Universidad Autónoma Metropolitana-Iztapalapa, México, DF, 09340, Mexico
Esqueda-León E.:
Departamento de Biologia de la Reproduccion y Clinica de Trastornos de Sueno, Universidad Autónoma Metropolitana-Iztapalapa, México, DF, 09340, Mexico
Terán-Pérez G.:
Departamento de Biologia de la Reproduccion y Clinica de Trastornos de Sueno, Universidad Autónoma Metropolitana-Iztapalapa, México, DF, 09340, Mexico
Gonzalez-Chavez A.:
Servicio de Medicina Interna, Hospital General de México, México, DF, 06726, Mexico
Escobedo G.:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Unidad Med Expt, Mexico City 06726, DF, Mexico
Gold
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