Antioxidant Capacity of ``Mexican Arnica'' Heterotheca inuloides Cass Natural Products and Some Derivatives: Their Anti-Inflammatory Evaluation and Effect on C. elegans Life Span
Por:
Rodríguez-Chávez J.L., Coballase-Urrutia E., Nieto-Camacho A., Delgado-Lamas G.
Publicada:
1 ene 2015
Resumen:
It has been suggested that the accumulation of biomolecular damage
caused by reactive oxygen species (ROS) contributes to aging. The
antioxidant activity is related to the ability of certain compounds to
protect against the potentially harmful effect of processes or reactions
involving ROS. This ability is associated with the termination of free
radical propagation in biological systems. From Heterotheca inuloides
various compounds which have shown to possess antioxidant capacity and
scavenging ROS. The aim of this study was to determine the antioxidant
capacity of additional natural components isolated from H. inuloides and
some semisynthetic derivatives, their anti-inflammatory activity and the
effect on Caenorhabditis elegans nematode life span. Compounds showed
ability to inhibit various biological processes such as lipid
peroxidation, scavenge nonbiological important oxidants such as O-1(2),
OH center dot, H2O2, and HOCl and scavenge non biological stable free
radicals (DPPH). Some cadinane type compounds showed possess
antioxidant, ROS scavenging capacity, anti-inflammatory activity, and
effect on the C. elegans life span. Flavonoid type compounds increased
the life of the nematode and quercetin was identified as the compound
with the greatest activity. The modification of chemical structure led
to a change in the antioxidant capacity, the anti-inflammatory activity,
and the survival of the worm.
Filiaciones:
Rodríguez-Chávez J.L.:
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, México, DF, 04510, Mexico
Coballase-Urrutia E.:
Laboratorio de Neuroquímica, Instituto Nacional de Pediatría, Insurgentes Sur 3700-C, México, DF, 04530, Mexico
Nieto-Camacho A.:
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, México, DF, 04510, Mexico
Delgado-Lamas G.:
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, México, DF, 04510, Mexico
Gold
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