Calmodulin inhibitors from natural sources: An update
Por:
Mata, R, Figueroa, M, GonzalezAndrade, M, RiveraChavez, JA, MadariagaMazon, A, Del Valle, P
Publicada:
1 mar 2015
Resumen:
Calmodulin (CaM) plays a central role in regulating a myriad of cellular functions in physiological and pathophysiological processes, thus representing an important drug target. In previous reviews, our group has reported relevant information regarding natural anti-CaM compounds up to 2009. Natural sources continue to provide a diverse and unique reservoir of CaM inhibitors for drug and research tool discovery. This review provides an update of natural products with reported CaM inhibitory properties, which includes around 70 natural products and some synthetic analogues, belonging to different structural classes. Most of these natural inhibitors were isolated from fungi and plants and belong to the stilbenoid, polyketide, alkaloid, and peptide structural classes. These products were discovered mainly using a fluorescence-based method on rationally designed biosensors, which are highly specific, low-cost, and selective and have short reaction times. The effect of several antimitotic drugs on Ca2+-hCaM is also described. © 2014 The American Chemical Society and American Society of Pharmacognosy.
Filiaciones:
Mata, R:
Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
Figueroa, M:
Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
GonzalezAndrade, M:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
RiveraChavez, JA:
Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
MadariagaMazon, A:
Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
Del Valle, P:
Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
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