fMRI subsequent source memory effects in young, middle-aged and old adults
Por:
Cansino S., Estrada-Manilla C., Trejo-Morales P., Pasaye-Alcaraz E.H., Aguilar-Castañeda E., Salgado-Lujambio P., Sosa-Ortiz A.L.
Publicada:
1 mar 2015
Categoría:
Behavioral Neuroscience
Resumen:
The ability to remember the spatial context in which our experiences
occur declines linearly across the adult lifespan. However, little is
known about whether this source memory decline is associated with neural
activity changes. In the present study, functional magnetic resonance
imaging (fMRI) scans were recorded in young, middle-aged and old adults
to investigate brain activity variations across the adult lifespan
during encoding of subsequent spatial source memory retrieval. Twelve
healthy individuals of both sexes were enrolled in each age group.
During encoding, participants performed natural/artificial judgment of
images of common objects that were randomly presented in one of the
quadrants of the screen. During retrieval, the images presented at
encoding were randomly mixed with new ones and displayed at the center
of the screen. Participants judged whether each image was new or old
and, if an image was old, they were instructed to indicate in which
quadrant the image was presented in the encoding session. The contrast
between study items that were later recognized and assigned a correct
source judgment with those whose sources were subsequently forgotten
revealed that positive subsequent memory effects disappear by middle age
in the left medial orbitofrontal gyrus and appear in the left superior
occipital gyrus. This under-recruitment and over-recruitment brain
activity was also present in old adults. The results allowed us to
identify the specific brain regions that first fail to encode spatial
information into an episodic representation during the adult lifespan.
(C) 2014 Elsevier B.V. All rights reserved.
Filiaciones:
Cansino S.:
Univ Nacl Autonoma Mexico, Fac Psychol, Lab NeuroCognit, Mexico City 04510, DF, Mexico
Estrada-Manilla C.:
Univ Nacl Autonoma Mexico, Fac Psychol, Lab NeuroCognit, Mexico City 04510, DF, Mexico
Trejo-Morales P.:
Univ Nacl Autonoma Mexico, Fac Psychol, Lab NeuroCognit, Mexico City 04510, DF, Mexico
Pasaye-Alcaraz E.H.:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Queretaro, Mexico
Aguilar-Castañeda E.:
Cognition and Behavior Unity, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
Salgado-Lujambio P.:
Department of Neuroimaging, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
Sosa-Ortiz A.L.:
Laboratory of Dementias, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
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