The Circadian Timing System: A Recent Addition in the Physiological Mechanisms Underlying Pathological and Aging Processes
Por:
Arellanes-Licea, E, Caldelas, I, De Ita-Perez, D, Diaz-Munoz, M
Publicada:
1 dic 2014
Resumen:
Experimental findings and clinical observations have strengthened the
association between physio-pathologic aspects of several diseases, as
well as aging process, with the occurrence and control of circadian
rhythms. The circadian system is composed by a principal pacemaker in
the suprachiasmatic nucleus (SNC) which is in coordination with a number
of peripheral circadian oscillators. Many pathological entities such as
metabolic syndrome, cancer and cardiovascular events are strongly
connected with a disruptive condition of the circadian cycle. Inadequate
circadian physiology can be elicited by genetic defects (mutations in
clock genes or circadian control genes) or physiological deficiencies
(desynchronization between SCN and peripheral oscillators). In this
review, we focus on the most recent experimental findings regarding
molecular defects in the molecular circadian clock and the altered
coordination in the circadian system that are related with clinical
conditions such as metabolic diseases, cancer predisposition and
physiological deficiencies associated to jet-lag and shiftwork
schedules. Implications in the aging process will be also reviewed.
Filiaciones:
Arellanes-Licea, E:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Caldelas, I:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico
De Ita-Perez, D:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Diaz-Munoz, M:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico
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