Mitochondria as a Target in the Therapeutic Properties of Curcumin
Por:
Trujillo J., Granados-Castro L.F., Zazueta C., Andérica-Romero A.C., Chirino Y.I., Pedraza-Chaverrí J.
Publicada:
1 dic 2014
Resumen:
Curcumin, a phenolic compound extracted from Curcuma longa, is commonly
used in Asia as a spice and pigment and has several biological
functions, particularly antioxidant properties. It has been reported
that curcumin exhibits bifunctional antioxidant properties related to
its capability to react directly with reactive oxygen species (ROS) and
also to its ability to induce the expression of cytoprotective and
antioxidant proteins through the transcription factor nuclear
factor-erythroid-2-related factor 2 (Nrf2). Recently, it has been
postulated that the mitochondrial function and metabolism are associated
with Nrf2 and that curcumin has shown activities against mitochondrial
dysfunction. The damage in mitochondria has been implicated in the
pathogenesis of diseases like diabetes, cancer, aging, and
neurodegenerative disorders. This review focuses on some of the most
recent findings of curcumin properties that suggest a close relationship
of this antioxidant with the mitochondrial function.
Filiaciones:
Trujillo J.:
Univ Nacl Autonoma Mexico, Dept Biol, Fac Quim, Mexico City, DF, Mexico
Granados-Castro L.F.:
Univ Nacl Autonoma Mexico, Dept Biol, Fac Quim, Mexico City, DF, Mexico
Zazueta C.:
Department of Cardiovascular Medicine, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., Mexico
Andérica-Romero A.C.:
Univ Nacl Autonoma Mexico, Dept Biol, Fac Quim, Mexico City, DF, Mexico
Chirino Y.I.:
Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Biomed, Mexico City, DF, Mexico
Pedraza-Chaverrí J.:
Univ Nacl Autonoma Mexico, Dept Biol, Fac Quim, Mexico City, DF, Mexico
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