Plasmodium falciparum M1-Aminopeptidase: A Promising Target for the Development of Antimalarials
Por:
González-Bacerio J., Fando R., Del Monte-Martínez A., Charli, JL, Chavez, MD
Publicada:
1 ene 2014
Resumen:
Malaria is a devastating human parasitic disease that receives enhanced
attention due to the emergence of resistance to traditional drugs. Thus,
the search for new molecular targets is a major goal. PfAM1 is an
aminopeptidase from Plasmodium falciparum, William H. Welch 1897,
belonging to the M1 family of metalloproteases, which is a promising
target of inhibitors to block the intra-erythrocytic stages of the
parasite. Since its identification in 1998, many efforts have been done
to validate PfAM1 as an appropriate target of antimalarials. The present
work is a critical review of the main structural, functional and kinetic
characteristics of PfAM1, as well as a summary of the effects of key
inhibitors at molecular and cellular levels. The systematization of
experimental results should contribute to a better understanding of the
properties of PfAM1 as a target of antimalarials and promote research
projects focused on the development of PfAM1 inhibitors.
Filiaciones:
González-Bacerio J.:
Centro de Estudio de Proteínas, Universidad de La Habana, 25 y J, La Habana, 10400, Cuba
Fando R.:
Centro Nacional de Investigaciones Científicas, Ave. 25 y 158, La Habana, 12100, Cuba
Del Monte-Martínez A.:
Centro de Estudio de Proteínas, Universidad de La Habana, 25 y J, La Habana, 10400, Cuba
Charli, JL:
Univ Nacl Autonoma Mexico, Inst Biotecnol, Cuernavaca 62210, Morelos, Mexico
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