Vitamin A increases nerve growth factor and retinoic acid receptor beta and improves diabetic neuropathy in rats
Por:
Hernández-Pedro N., Granados-Soto V., Ordonez, G, Pineda B., Rangel-López E., Salazar-Ramiro A., Arrieta O., Sotelo J.
Publicada:
1 sep 2014
Resumen:
All-trans retinoic acid (ATRA) promotes the endogenous expression of both nerve growth factor (NGF) and retinoic acid receptor beta (RAR-beta). We have previously shown that the administration of ATRA partly reverts the damage induced by diabetic neuropathy (DN). In this investigation, we evaluated the effects of vitamin A, a commercial, inexpensive compound of retinoic acid, on the therapy of DN. A total of 70 rats were randomized into 4 groups. Group A was the control, and groups B, C, and D received a total dose of 60 mg/kg streptozotocin intraperitoneally. When signs of DN developed, groups C and D were treated either with vitamin A (20,000 IU) or with ATRA 25 mg/kg for 60 days. Plasma glucose, contents of NGF, thermal and nociceptive tests, and RAR-beta expression were evaluated. All diabetic rats developed neuropathy. The treatment with vitamin A and ATRA reverted similarly the sensorial disturbances, which was associated with increased contents of NGF and RAR-beta expression. Ou
Filiaciones:
Hernández-Pedro N.:
Neuroimmunology Unit, Instituto Nacional de Neurología y Neurocirugía (INNN), Insurgentes sur 3877, 14269, Mexico City, Mexico
Granados-Soto V.:
Departamento de Farmacobiología, Centro de Investigación y Estudios Avanzados (CINVESTAV) Sede sur, Mexico City, Mexico
Pineda B.:
Neuroimmunology Unit, Instituto Nacional de Neurología y Neurocirugía (INNN), Insurgentes sur 3877, 14269, Mexico City, Mexico
Rangel-López E.:
Excitatory Amino Acids Laboratory, Instituto Nacional de Neurología y Neurocirugía (INNN), Mexico City, Mexico
Salazar-Ramiro A.:
Neuroimmunology Unit, Instituto Nacional de Neurología y Neurocirugía (INNN), Insurgentes sur 3877, 14269, Mexico City, Mexico
Arrieta O.:
Department of Medical Oncology, Laboratory of Experimental Oncology, Instituto Nacional de Cancerologia (INCAN), Mexico City, Mexico
Sotelo J.:
Neuroimmunology Unit, Instituto Nacional de Neurología y Neurocirugía (INNN), Insurgentes sur 3877, 14269, Mexico City, Mexico
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