Molecular epidemiology of influenza A/H3N2 viruses circulating in Mexico from 2003 to 2012
Por:
Escalera-Zamudio M., Nelson M.I., Guemes, AGC, López-Martínez I., Cruz-Ortiz N., Iguala-Vidales M., García E.R., Barrera-Badillo G., Díaz-Quiñonez J.A., López S., Arias C.F., Isa P.
Publicada:
30 jul 2014
Resumen:
In this work, nineteen influenza A/H3N2 viruses isolated in Mexico between 2003 and 2012 were studied. Our findings show that different human A/H3N2 viral lineages co-circulate within a same season and can also persist locally in between different influenza seasons, increasing the chance for genetic reassortment events. A novel minor cluster was also identified, named here as Korea, that circulated worldwide during 2003. Frequently, phylogenetic characterization did not correlate with the determined antigenic identity, supporting the need for the use of molecular evolutionary tools additionally to antigenic data for the surveillance and characterization of viral diversity during each flu season. This work represents the first long-term molecular epidemiology study of influenza A/H3N2 viruses in Mexico based on the complete genomic sequences and contributes to the monitoring of evolutionary trends of A/H3N2 influenza viruses within North and Central America. © 2014 Escalera-Zamudio et al.
Filiaciones:
Escalera-Zamudio M.:
Univ Nacl Autonoma Mexico, Inst Biotecnol, Cuernavaca 62191, Morelos, Mexico
Nelson M.I.:
Fogarty International Center, National Institutes of Health, Bethesda, MD, United States
Guemes, AGC:
Univ Nacl Autonoma Mexico, Inst Biotecnol, Cuernavaca 62191, Morelos, Mexico
López-Martínez I.:
Instituto de Diagnóstico Y Referencia Epidemiológicos, México D.F, Mexico
Cruz-Ortiz N.:
Instituto de Diagnóstico Y Referencia Epidemiológicos, México D.F, Mexico
Iguala-Vidales M.:
Instituto de Diagnóstico Y Referencia Epidemiológicos, México D.F, Mexico
García E.R.:
Instituto de Diagnóstico Y Referencia Epidemiológicos, México D.F, Mexico
Barrera-Badillo G.:
Instituto de Diagnóstico Y Referencia Epidemiológicos, México D.F, Mexico
Díaz-Quiñonez J.A.:
Instituto de Diagnóstico Y Referencia Epidemiológicos, México D.F, Mexico
López S.:
Univ Nacl Autonoma Mexico, Inst Biotecnol, Cuernavaca 62191, Morelos, Mexico
Arias C.F.:
Univ Nacl Autonoma Mexico, Inst Biotecnol, Cuernavaca 62191, Morelos, Mexico
Isa P.:
Univ Nacl Autonoma Mexico, Inst Biotecnol, Cuernavaca 62191, Morelos, Mexico
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