Anthraquinones from Vismia mexicana
Por:
Reyes-Chilpa R., Gómez-Cansino R., Guzmán-Gutiérrez S.L., Hernández-Ortega S., Campos-Lara M., Vega-Avila E., Nieto-Camacho A.
Publicada:
1 ene 2014
Categoría:
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Resumen:
Vismia mexicana (Clusiaceae) is a small tropical tree found from Mexico to Honduras. The CH2Cl2/MeOH extract from the leaves has been reported to have inhibitory properties against reverse transcriptase of human immunodeficiency virus type 1 (HIV-1 RT). In order to characterize some of its chemical constituents, the EtOAc-soluble fraction of this extract was subjected to column chromatography. A new natural product was isolated and designated vismiaquinone D [1-hydroxy-6- methoxy-7,8-(3',3'-dimethyl-pyrano) anthraquinone]. In addition, vismiaquinone was obtained. The structures of vismiaquinone and vismiaquinone D were determined by 1H and 13C NMR spectroscopy, unambiguous assignments were achieved with DEPT, HSQC, and HMBC experiments, and corroborated by X-ray diffraction studies. The isolated anthraquinones were tested against HIV-1 RT. However, none showed relevant activity, suggesting that other compounds in this extract may be responsible for its HIV-1 RT inhibitory properties. © 2014 Verlag der Zeitschrift für Naturforschung, Tübingen.
Filiaciones:
Reyes-Chilpa R.:
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
Gómez-Cansino R.:
Univ Nacl Autonoma Mexico, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
Guzmán-Gutiérrez S.L.:
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
Hernández-Ortega S.:
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
Campos-Lara M.:
Unidad de Investigación en Farmacología, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc 330, Del. Cuauhtémoc, 06720, México, DF, Mexico
Vega-Avila E.:
Universidad Autónoma Metropolitana, Unidad Iztapalapa, Departamento de Ciencias de la Salud, San Rafael Atlixco 186, Del. Iztapalapa, 09340, México, DF, Mexico
Nieto-Camacho A.:
Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
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