Myosin 1g regulates cytoskeleton plasticity,cell migration,exocytosis,and endocytosis in B lymphocytes
Por:
Maravillas-Montero J.L., López-Ortega O., Patino-Lopez, G, Santos-Argumedo L.
Publicada:
1 mar 2014
Resumen:
Myosin 1g (Myo1g) is a hematopoietic-specific myosin expressed mainly by lymphocytes. Here, we report the localization of Myo1g in B-cell membrane compartments such as lipid rafts, microvilli, and membrane extensions formed during spreading. By using Myo1g-deficient mouse B cells, we detected abnormalities in the adhesion ability and chemokine-induced directed migration of these lymphocytes. We also assessed a role for Myo1g in phagocytosis and exocytosis processes, as these were also irregular in Myo1g-deficient B cells. Taken together, our results show that Myo1g acts as a main regulator of different membrane/cytoskeleton-dependent processes in B lymphocytes.
Filiaciones:
Maravillas-Montero J.L.:
Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, Mexico
López-Ortega O.:
Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, Mexico
Santos-Argumedo L.:
Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, Mexico
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States
Laboratorio de Investigación en Inmunología, Hospital Infantil de México, Federico Gómez, CP 06720, Ciudad de México, Mexico
Bronze
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