HLA Class I and Class II Conserved Extended Haplotypes and Their Fragments or Blocks in Mexicans: Implications for the Study of Genetic Diversity in Admixed Populations


Por: Zuniga, J, Yu N., Barquera R., Alosco S., Ohashi M., Lebedeva T., Acuna-Alonzo, V, Yunis M., Granados-Montiel J., Cruz-Lagunas A., Vargas-Alarcón G., Rodríguez-Reyna T.S., Fernandez-Viña M., Granados J., Yunis E.J.

Publicada: 23 sep 2013
Resumen:
Major histocompatibility complex (MHC) genes are highly polymorphic and informative in disease association, transplantation, and population genetics studies with particular importance in the understanding of human population diversity and evolution. The aim of this study was to describe the HLA diversity in Mexican admixed individuals. We studied the polymorphism of MHC class I (HLA-A, -B, -C), and class II (HLA-DRB1, -DQB1) genes using high-resolution sequence based typing (SBT) method and we structured the blocks and conserved extended haplotypes (CEHs) in 234 non-related admixed Mexican individuals (468 haplotypes) by a maximum likelihood method. We found that HLA blocks and CEHs are primarily from Amerindian and Caucasian origin, with smaller participation of African and recent Asian ancestry, demonstrating a great diversity of HLA blocks and CEHs in Mexicans from the central area of Mexico. We also analyzed the degree of admixture in this group using short tandem repeats (STRs) and HLA-B that correlated with the frequency of most probable ancestral HLA-C/-B and -DRB1/-DQB1 blocks and CEHs. Our results contribute to the analysis of the diversity and ancestral contribution of HLA class I and HLA class II alleles and haplotypes of Mexican admixed individuals from Mexico City. This work will help as a reference to improve future studies in Mexicans regarding allotransplantation, immune responses and disease associations. © 2013 Zuñiga et al.

Filiaciones:
Yu N.:
 HLA Laboratory, The American Red Cross Northeast Division, Dedham, MA, United States

Barquera R.:
 Molecular Genetics Laboratory, National School of Anthropology and History, Mexico City, Mexico

Alosco S.:
 HLA Laboratory, The American Red Cross Northeast Division, Dedham, MA, United States

Ohashi M.:
 HLA Laboratory, The American Red Cross Northeast Division, Dedham, MA, United States

Lebedeva T.:
 HLA Laboratory, The American Red Cross Northeast Division, Dedham, MA, United States

Yunis M.:
 Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, United States

Granados-Montiel J.:
 Tissue Engineering, Cell Therapy and Regenerative Medicine Research Unit, Instituto Nacional de Rehabilitación, Mexico City, Mexico

Cruz-Lagunas A.:
 Department of Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico

Vargas-Alarcón G.:
 Laboratory of Genomics, Instituto Nacional de Cardiología Ignacio Chavez, Mexico City, Mexico

Rodríguez-Reyna T.S.:
 Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

Fernandez-Viña M.:
 Department of Pathology, Stanford University, Stanford, CA, United States

Granados J.:
 Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

Yunis E.J.:
 Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, United States
ISSN: 19326203
Editorial
PUBLIC LIBRARY SCIENCE, 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 8 Número: 9
Páginas:
WOS Id: 000326520200031
ID de PubMed: 24086347
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