Respiratory disease in growing pigs after Porcine rubulavirus experimental infection
Por:
Rivera-Benitez J.F., Cuevas-Romero S., Pérez-Torres A., Reyes-Leyva J., Hernández J., Ramírez-Mendoza H.
Publicada:
1 sep 2013
Resumen:
The aim of this study was to analyze the pathogenicity and distribution of Porcine rubulavirus (PorPV) in the respiratory tract of experimentally infected pigs. Nine 6-week-old pigs were infected with PorPV and examined clinically. Blood, nasal swab, and tissue samples were collected on different days post-infection (DPI). The humoral immune responses and viral loads were evaluated. The infected pigs exhibited an increase in the respiratory clinical signs. In addition, the excretion of PorPV was extended to 23 DPI in the nasal fluid. The distribution of PorPV in the respiratory tract tissues was extended until the end of the experiment; soft palate tonsil and lymph nodes exhibited high viral loads. The major microscopic lesions observed in the lungs corresponded to interstitial pneumonia and hyperplasia of the associated lymphoid tissue. In conclusion, PorPV infection causes a pneumonic disease characterized by a prolonged virus excretion and high viral load in the lymphoid tissues. © 2013 Elsevier B.V.
Filiaciones:
Rivera-Benitez J.F.:
Univ Nacl Autonoma Mexico, Dept Microbiol & Inmunol, Fac Med Vet & Zootecnia, Mexico City 04510, DF, Mexico
Cuevas-Romero S.:
Centro Nacional de Investigación Disciplinaria en Microbiología Animal, Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, Distrito Federal, Mexico
Pérez-Torres A.:
Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
Reyes-Leyva J.:
Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico
Hernández J.:
Centro de Investigación en Alimentación y Desarrollo, A.C. Sonora, Mexico
Ramírez-Mendoza H.:
Univ Nacl Autonoma Mexico, Dept Microbiol & Inmunol, Fac Med Vet & Zootecnia, Mexico City 04510, DF, Mexico
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