A noncanonical NF-kappa B pathway through the p50 subunit regulates Bcl-2 overexpression during an oxidative-conditioning hormesis response
Por:
Luna-López A., González-Puertos V.Y., Romero-Ontiveros J., Ventura-Gallegos J.L., Zentella A., Gomez-Quiroz L.E., Konigsberg, M
Publicada:
1 oct 2013
Resumen:
Cells can respond to damage and stress by activating various repair and
survival pathways. One of these responses can be induced by
preconditioning the cells with sublethal stress to provoke a prosurvival
response that will prevent damage and death, and which is known as
hormesis. Bcl-2, an antiapoptotic protein recognized by its antioxidant
and prosurvival functions, has been documented to play an important role
during oxidative-conditioning hormesis. Using an oxidative-hormetic
model, which was previously established in the L929 cell line by
subjecting the cells to a mild oxidative stress of 50 mu M H2O2 for 9 h,
we identified two different transductional mechanisms that participate
in the regulation of Bcl-2 expression during the hormetic response.
These mechanisms converge in activating the nuclear transcription factor
NF-kappa B. Interestingly, the noncanonical p50 subunit of the NF-kappa
B family is apparently the subunit that participates during the
oxidative-hormetic response. (C) 2013 Elsevier Inc. All rights reserved.
Filiaciones:
Luna-López A.:
Instituto Nacional de Geriatría, SSA, México, DF 10200, Mexico
González-Puertos V.Y.:
Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana Iztapalapa, México, DF 09340, Mexico
Romero-Ontiveros J.:
Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana Iztapalapa, México, DF 09340, Mexico
Ventura-Gallegos J.L.:
Univ Nacl Autonoma Mexico, IIB, Dept Med Genom & Toxicol Ambiental, Mexico City 04510, DF, Mexico
Zentella A.:
Univ Nacl Autonoma Mexico, IIB, Dept Med Genom & Toxicol Ambiental, Mexico City 04510, DF, Mexico
Gomez-Quiroz L.E.:
Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana Iztapalapa, México, DF 09340, Mexico
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