Antiapoptotic effects of EGb 761
Por:
Serrano-García N., Pedraza-Chaverri J., Mares-Sámano J.J., Orozco-Ibarra M., Cruz-Salgado A., Jiménez-Anguiano A., Sotelo J., Trejo-Solís C.
Publicada:
1 ene 2013
Categoría:
Complementary and Alternative Medicine
Resumen:
Ginkgo biloba extracts have long been used in Chinese traditional medicine for hundreds of years. The most significant extract obtained from Ginkgo biloba leaves has been EGb 761, a widely used phytopharmaceutical product in Europe. EGb 761 is a well-defined mixture of active compounds, which contains two main active substances: flavonoid glycosides (24-26%) and terpene lactones (6-8%). These compounds have shown antiapoptotic effects through the protection of mitochondrial membrane integrity, inhibition of mitochondrial cytochrome c release, enhancement of antiapoptotic protein transcription, and reduction of caspase transcription and DNA fragmentation. Other effects include the reduction of oxidative stress (which has been related to the occurrence of vascular, degenerative, and proliferative diseases), coupled to strong induction of phase II-detoxifying and cellular defense enzymes by Nrf2/ARE activation, in addition to the modulation of transcription factors, such as CREB, HIF-1a, NF-B, AP-1, and p53, involved in the apoptosis process. This work reviews experimental results about the antiapoptotic effects induced by the standardized extract of Ginkgo biloba leaves (EGb 761). © 2013 Norma Serrano-García et al.
Filiaciones:
Serrano-García N.:
Univ Nacl Autonoma Mexico, Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, Lab Neurobiol Mol & Celular, INNN, Mexico City, DF, Mexico
Pedraza-Chaverri J.:
Univ Nacl Autonoma Mexico, Dept Biol, Fac Quim, Mexico City 04510, DF, Mexico
Mares-Sámano J.J.:
Laboratorio Analítico de Compuestos Del Tabaco, Instituto Nacional de Salud Pública, 014000 México, DF, Mexico
Orozco-Ibarra M.:
Univ Nacl Autonoma Mexico, Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, Lab Neurobiol Mol & Celular, INNN, Mexico City, DF, Mexico
Cruz-Salgado A.:
Departamento de Salud Bucal, Centro Nacional de Programas Preventivo y Control de Enfermedades, 11800 México, DF, Mexico
Jiménez-Anguiano A.:
Área de Neurociencias, Departamento de Biología de la Reproducción, Universidad Autónoma Metropolitana-Iztapalapa, 09340 México, DF, Mexico
Sotelo J.:
Departamento de Neuroinmunología, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, 14269 México, DF, Mexico
Trejo-Solís C.:
Departamento de Neuroinmunología, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, 14269 México, DF, Mexico
Gold
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