Gene expression profiles of nucleus accumbens, prefrontal cortex and hippocampus in an animal model of schizophrenia: proposed candidate genes
Por:
Genis-Mendoza A.D., Gallegos-Silva R.I., López-Casamichana M., López-Rubalcava C., Nicolini H.
Publicada:
1 may 2013
Categoría:
Psychiatry and Mental Health
Resumen:
Introduction: It has been suggested that schizophrenia may be induced by "accidents" or injuries that occur during early brain development and result in a reduction of the neural connections in different regions. In this study, we evaluated differences in the expression of brain genes using a recognized experimental prototype of schizophrenia: the animal model of ventral hippocampal lesion in neonate rats (VHLN) compared to control animals. Methods: Using microarray technology, we obtained gene expression profiles of three brain areas (nucleus accumbens, prefrontal cortex and hippocampus) of juvenile (45 days) and adult (90 days) Wistar male rats that underwent either VHLN or sham VHLN. Results: Based on three criteria: 1) expression in more than one brain area, 2) participation in cellular pathways relevant to the central nervous system (CNS), 3) Z-score values >2 (overexpression) and <-2 (underexpression), we found overexpression of the ppp3cb, dctn1, jag1, ide, limk2 and cpz genes a
Filiaciones:
Genis-Mendoza A.D.:
Universidad Autónoma de la Ciudad de México, D.F. México, Mexico
Instituto Nacional de Medicina Genómica Servicios de Atención Psiquiátrica, Secretaria de Salud D.F. México, Mexico
Gallegos-Silva R.I.:
Universidad Autónoma de la Ciudad de México, D.F. México, Mexico
López-Casamichana M.:
Universidad Autónoma de la Ciudad de México, D.F. México, Mexico
López-Rubalcava C.:
Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-Sede Sur), Departamento de Fármaco-Biología, D.F. México, Mexico
Nicolini H.:
Universidad Autónoma de la Ciudad de México, D.F. México, Mexico
Instituto Nacional de Medicina Genómica Servicios de Atención Psiquiátrica, Secretaria de Salud D.F. México, Mexico
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