Tamoxifen Treatment in Hamsters Induces Protection during Taeniosis by Taenia solium
Por:
Escobedo G., Palacios-Arreola M.I., Olivos A., López-Griego L., Morales-Montor J.
Publicada:
1 ene 2013
Resumen:
Human neurocysticercosis by Taenia solium is considered an emergent
severe brain disorder in developing and developed countries. Discovery
of new antiparasitic drugs has been recently aimed to restrain
differentiation and establishment of the T. solium adult tapeworm, for
being considered a central node in the disease propagation to both pigs
and humans. Tamoxifen is an antiestrogenic drug with cysticidal action
on Taenia crassiceps, a close relative of T. solium.. us, we evaluated
the effect of tamoxifen on the in vitro evagination and the in vivo
establishment of T. solium. In vitro, tamoxifen inhibited evagination of
T. solium cysticerci in a dose-time dependent manner. In vivo,
administration of tamoxifen to hamsters decreased the intestinal
establishment of the parasite by 70%, while recovered tapeworms showed
an 80% reduction in length, appearing as scolices without strobilar
development. Since tamoxifen did not show any significant effect on the
proliferation of antigen-specific immune cells, intestinal inflammation,
and expression of Th1/Th2 cytokines in spleen and duodenum, this drug
could exert its antiparasite actions by having direct detrimental
effects upon the adult tapeworm. These results demonstrate that
tamoxifen exhibits a strong cysticidal and antitaeniasic effect on T.
solium that should be further explored in humans and livestock.
Filiaciones:
Escobedo G.:
Unidad de Medicina Experimental, Hospital General de México, México, DF 06726, Mexico
Palacios-Arreola M.I.:
Univ Nacl Autonoma Mexico, Dept Inmunol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Olivos A.:
Departamento de Medicina Experimental, Hospital General de México, Universidad Nacional Autónoma de México, México, DF 06726, Mexico
López-Griego L.:
Univ Nacl Autonoma Mexico, Dept Inmunol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Morales-Montor J.:
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, México, DF 04510, Mexico
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