Alternatively Activated Macrophages in Types 1 and 2 Diabetes
Por:
Espinoza-Jimenez, A, Peon, AN, Terrazas, LI
Publicada:
1 ene 2012
Resumen:
Macrophages are innate immune cells derived from monocytes, which, in turn, arise from myeloid precursor cells in the bone marrow. Macrophages have many important roles in the innate and adaptive immune response, as well as in tissue homeostasis. Two major populations have been defined: The classically activated macrophages that respond to intracellular pathogens by secreting proinflammatory cytokines and reactive oxygen species and alternatively activated macrophages which are induced during Th2 responses displaying anti-inflammatory activities. Both macrophage populations are central players in diabetes, the first one triggering inflammatory responses which initiates insulitis and pancreatic beta cell death during type 1 diabetes, whereas the second population decreases hyperglycemia, insulitis, and inflammation in the pancreas, thereby negatively regulate type 1 diabetes. Obesity is an important factor in the development of type 2 diabetes; classically activated macrophages are a do
Filiaciones:
Espinoza-Jimenez, A:
Univ Nacl Autonoma Mexico, Unidad Biomed, Fac Estudios Super Iztacala, Tlalnepantla 54090, Mex, Mexico
Peon, AN:
Univ Nacl Autonoma Mexico, Unidad Biomed, Fac Estudios Super Iztacala, Tlalnepantla 54090, Mex, Mexico
Terrazas, LI:
Univ Nacl Autonoma Mexico, Unidad Biomed, Fac Estudios Super Iztacala, Tlalnepantla 54090, Mex, Mexico
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