Sialyl Lewis x expression in cervical scrapes of premalignant lesions
Por:
Velázquez-Márquez N., Santos-López G., Jiménez-Aranda L., Reyes-Leyva J., Vallejo-Ruiz V.
Publicada:
1 dic 2012
Resumen:
Sialylated oligosaccharides of glycoproteins and glycolipids have been implicated in tumour progression and metastases. Altered expression of glycosidic antigens has been reported in cervical cancer. In cervix premalignant lesions, an increased expression of sialic acid has been reported. In the present study we determined the expression profiles of the glycosidic antigens Tn, sialyl Tn (sTn), Lewis a (Le(a)), sialyl Lewis a (sLe(a)), Lewis x (Le(x)) and sialyl Lewis x (sLe(x)) in cervical scrapes with cytological diagnoses of normal, low-grade squamous intraepithelial lesions (LGSIL) and high-grade squamous intraepithelial lesions (HGSIL). Cervical scrapings were collected to detect tumour antigens expressions by flow cytometry using monoclonal antibodies. Cytometry analysis of Tn, sTn, Le(a) and Le(x) did not reveal differences at the expression level among groups. The number of positive cells to sLe(a) antigen increased in the HGSIL group with respect to the normal group (p=0.0495).
Filiaciones:
Velázquez-Márquez N.:
Laboratorio de Biología Molecular y Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Carretera Federal Atlixco-Metepec, Atlixco, Puebla, Mexico C.P. 74360, Mexico
Santos-López G.:
Laboratorio de Biología Molecular y Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Carretera Federal Atlixco-Metepec, Atlixco, Puebla, Mexico C.P. 74360, Mexico
Jiménez-Aranda L.:
Clínica de Displasias, Hospital General de Zona No. 1, Instituto Mexicano del Seguro Social, Tlaxcala, Tlaxcala, Mexico, Mexico
Reyes-Leyva J.:
Laboratorio de Biología Molecular y Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Carretera Federal Atlixco-Metepec, Atlixco, Puebla, Mexico C.P. 74360, Mexico
Vallejo-Ruiz V.:
Laboratorio de Biología Molecular y Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Carretera Federal Atlixco-Metepec, Atlixco, Puebla, Mexico C.P. 74360, Mexico
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