Effects of subcutaneous administration of caffeine on the physiometabolic profile of low-birthweight neonate piglets
Por:
Orozco-Gregorio H., Bonilla-Jaime H., Mota-Rojas D., Trujillo-Ortega M.E., Roldan-Santiago P., Martinez-Rodriguez, R, Borderas-Tordesillas F., Flores-Peinado S., Mora-Medina P., Ramirez-Necoechea, R
Publicada:
1 ene 2012
Resumen:
Caffeine administration has been used to stimulate respiration and reverse metabolic alterations in high-birthweight piglets that suffer neonatal asphyxia. However, its effect has not been evaluated on low-birthweight neonates. This study determined the effect of subcutaneously administering caffeine on the physiometabolic profile of neonate piglets with low birthweight and neonatal asphyxia. A 35-mg subcutaneous dose of caffeine, or an equivalent placebo, was randomly administered at 0 and 24 h to neonate piglets (n = 120) diagnosed with intrapartum asphyxia and classified as low-(LW) or high weight (HW) in a 2 by 2 experimental design. Blood samples were obtained at 0, 2 and 24 h postpartum. At 2 h, blood glucose concentrations diminished in the animals in both groups that were treated with caffeine (P < 0.005). Of those animals, only the ones in HW showed increased glucose concentrations by 24 h. At 0 h, group LW exhibited the highest levels of pCO(2) (P < 0.005). In contrast, from
Filiaciones:
Orozco-Gregorio H.:
Doctoral Program in Biological Sciences and Health, Universidad Autónoma Metropolitana, Iztapalapa/Xochimilco, México D.F., Mexico
Universidad Autónoma Metropolitana, Xochimilco, Stress Physiology and Farm Animal Welfare, Department of Animal Production and Agriculture, Calzada del Hueso 1100, Col. Villa Quietud, México D.F., 04960, Mexico
Bonilla-Jaime H.:
Universidad Autónoma Metropolitana, Iztapalapa, Department of Reproductive Biology, México D.F., Mexico
Mota-Rojas D.:
Universidad Autónoma Metropolitana, Xochimilco, Stress Physiology and Farm Animal Welfare, Department of Animal Production and Agriculture, Calzada del Hueso 1100, Col. Villa Quietud, México D.F., 04960, Mexico
Trujillo-Ortega M.E.:
Univ Nacl Autonoma Mexico, Dept Anim Med & Prod, Fac Vet & Anim Prod, Mexico City 04510, DF, Mexico
Roldan-Santiago P.:
Universidad Autónoma Metropolitana, Xochimilco, Stress Physiology and Farm Animal Welfare, Department of Animal Production and Agriculture, Calzada del Hueso 1100, Col. Villa Quietud, México D.F., 04960, Mexico
Martinez-Rodriguez, R:
Univ Nacl Autonoma Mexico, Ctr Teaching Res & Extens Swine Prod CEIEPP, Fac Vet & Anim Prod, Mexico City 04510, DF, Mexico
Borderas-Tordesillas F.:
Universidad Autónoma Metropolitana, Xochimilco, Stress Physiology and Farm Animal Welfare, Department of Animal Production and Agriculture, Calzada del Hueso 1100, Col. Villa Quietud, México D.F., 04960, Mexico
Flores-Peinado S.:
Univ Nacl Autonoma Mexico, Dept Livestock Sci, Fac Estudios Super Cuautitlan, Mexico City 04510, DF, Mexico
Mora-Medina P.:
Univ Nacl Autonoma Mexico, Dept Livestock Sci, Fac Estudios Super Cuautitlan, Mexico City 04510, DF, Mexico
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