The age-dependent change in Olfactory periglomerular neuronal populations is not affected by interrupting subventricular neuroblast migration in adult rats
Por:
Contreras-García J.I., Rodríguez-Castañeda L., Gómez-Lira G., Ramírez-Hernández R., Villafán H., Granados-Rojas L., Gutiérrez-Ospina G., Torreblanca, JGM
Publicada:
26 jul 2012
Categoría:
Neuroscience (miscellaneous)
Resumen:
The olfactory bulb (OB) is rich in the number and variety of neurotransmitter and neuropeptide containing cells, in particular in the glomerular layer. Several reports suggest that numbers of some periglomerular phenotypes could change depending on age. However, it is unclear whether the different classes of periglomerular interneurons are modified or are maintained stable throughout life. Thus, our first objective was to obtain the absolute number of cells belonging to the different periglomerular phenotypes at adulthood. On the other hand, the olfactory bulb is continously supplied with newly generated periglomerular neurons produced by stem cells located in the subventricular zone (SVZ) and rostral migratory stream. Previously, we demonstrated that the implantation of a physical barrier completely prevents SVZ neuroblast migration towards the OB. Then, another objective of this study was to evaluate whether stopping the continuous supply of SVZ neuroblasts modified the different per
Filiaciones:
Contreras-García J.I.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Biol Celular & Fisiol, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Grp Invest Celulas Troncales IMPULSA 02, Mexico City 04510, DF, Mexico
Rodríguez-Castañeda L.:
Laboratorio de Neuromorfometría, Instituto Nacional de Pediatría, Insurgentes Sur 3700-C, Col. Insurgentes Cuicuilco, 04530 México, D.F., Mexico
Gómez-Lira G.:
Laboratorio de Neuromorfometría, Instituto Nacional de Pediatría, Insurgentes Sur 3700-C, Col. Insurgentes Cuicuilco, 04530 México, D.F., Mexico
Ramírez-Hernández R.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Biol Celular & Fisiol, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Grp Invest Celulas Troncales IMPULSA 02, Mexico City 04510, DF, Mexico
Villafán H.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Biol Celular & Fisiol, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Grp Invest Celulas Troncales IMPULSA 02, Mexico City 04510, DF, Mexico
Granados-Rojas L.:
Laboratorio de Neuromorfometría, Instituto Nacional de Pediatría, Insurgentes Sur 3700-C, Col. Insurgentes Cuicuilco, 04530 México, D.F., Mexico
Gutiérrez-Ospina G.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Biol Celular & Fisiol, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Grp Invest Celulas Troncales IMPULSA 02, Mexico City 04510, DF, Mexico
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