Arylamine N-acetyltransferase 2 genotypes in a Mexican population
Por:
Taja-Chayeb L., Agúndez J.A., Miguez-Muñoz C., Chavez-Blanco A., Duenas-Gonzalez, A
Publicada:
1 ene 2012
Resumen:
The acetylating activity of N-acetyltransferase 2 (NAT2) has critical implications for therapeutics and disease susceptibility. To date, several polymorphisms that alter the enzymatic activity and/or protein stability of NAT2 have been identified. We examined the distribution and frequency of NAT2 genotypes in the Mexican population. Among 250 samples amplified and sequenced for the NAT2 gene, we found seven different SNPs; the most frequent allele was 803 A>G (35.8%), followed by 282 C>T, 341 T>C, and 481 C>T. There were no differences in the distribution of SNPs between healthy subjects and cancer patients. These eight polymorphisms defined 26 diplotypes; 11.6% were wild type (NAT2*4/NAT2*4), while the most common diplotype was NAT2*4/NAT2*5B, present in 17.2%. We did not identify other common polymorphisms. The results were compared with the NAT2 SNPs reported from other populations. All but the Turkish population was significantly different from ours. We conclude that the mixed-rac
Filiaciones:
Taja-Chayeb L.:
Division of Basic Research, National Cancer Institute of Mexico, Mexico City, Mexico
Agúndez J.A.:
Department of Pharmacology, Extremadura University, Cáceres, Spain
Miguez-Muñoz C.:
Division of Basic Research, National Cancer Institute of Mexico, Mexico City, Mexico
Chavez-Blanco A.:
Division of Basic Research, National Cancer Institute of Mexico, Mexico City, Mexico
Duenas-Gonzalez, A:
Univ Nacl Autonoma Mexico, Natl Canc Inst Mexico, Inst Biomed Res, Unit Biomed Res Canc, Mexico City 04510, DF, Mexico
Bronze
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