Vaccination of mice with recombinant bacille Calmette-Guerin harboring Rv1357c protects similarly to native BCG
Por:
Flores-Valdez M.A., Aceves-Sanchez, MD, Montero-Pérez S.A., Sánchez-López A.D., Gutiérrez-Pabello J.A., Hernández-Pando R.
Publicada:
1 jun 2012
Resumen:
Despite the availability of a Mycobacterium bovis bacille Calmette Guerin (BCG) vaccine, tuberculosis (TB) remains a global public health problem. In this study, we introduced the c-di-GMP phosphodiesterase gene Rv1357c, implicated in regulating mycobacterial replication within macrophages, into BCG Pasteur, and tested the resulting strain for capacity to serve as a vaccine against TB in a murine model. Modified BCG was more phagocytosed than its parental strain, but halted bacterial replication, and protected against M. tuberculosis challenge similarity to unmodified BCG.
Filiaciones:
Flores-Valdez M.A.:
Biotecnología Médica Y Farmacéutica, Centro de Investigacion Y Asistencia en Tecnologia Y Diseno del Estado de Jalisco AC, Guadalajara, Jalisco, Mexico
Montero-Pérez S.A.:
Biotecnología Médica Y Farmacéutica, Centro de Investigacion Y Asistencia en Tecnologia Y Diseno del Estado de Jalisco AC, Guadalajara, Jalisco, Mexico
Sánchez-López A.D.:
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Mexico City 04510, DF, Mexico
Gutiérrez-Pabello J.A.:
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Mexico City 04510, DF, Mexico
Hernández-Pando R.:
Instituto Nacional de la Nutrición Y Ciencias Médicas Salvador Zubirán, Mexico City, Mexico
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