Parameters affecting drug release from inert matrices. 1: Monte Carlo simulation
Por:
Villalobos R., Viquez H., Hernández B., Ganem A., Melgoza L.M., Young P.M.
Publicada:
1 may 2012
Categoría:
Pharmaceutical Science
Resumen:
This study investigates the use of Monte Carlo simulation for the determination of release properties from cubic inert matrices. Specifically, the study has focused on factors including porosity, surface area and tortuosity. The release platform was formed by simulating matrices with different ratios of drug and excipient, which undergo drug release in a uni-directional (two-face) or omni-directional (six-face) process. Upon completion of each simulation the matrix 'carcass' was examined and porosity and tortuosity of the medium evaluated. The tortuosity of the medium was evaluated directly by a blind random walk algorithm. These parameters as well as the release profile were then studied with respect to common mathematical models describing drug diffusion (the square-root, power and Weibull models). It was found that, depending on their composition, the matrices systems were either homogeneous or heterogeneous in nature. Furthermore, it was found that the physical parameters could be
Filiaciones:
Villalobos R.:
UNAM, Fac Estudios Super Cuautitlan, Div Estudios Posgrad Tecnol Farmaceut, Cuautitlan 54740, Estado De Mexic, Mexico
División de Estudios de Posgrado (Tecnología Farmacéutica), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Av. Primero de Mayo S/N, Cuautitlan Izcalli. C.P. 54740, Estado de Mexico, Mexico
Viquez H.:
UNAM, Fac Estudios Super Cuautitlan, Div Estudios Posgrad Tecnol Farmaceut, Cuautitlan 54740, Estado De Mexic, Mexico
División de Estudios de Posgrado (Tecnología Farmacéutica), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Av. Primero de Mayo S/N, Cuautitlan Izcalli. C.P. 54740, Estado de Mexico, Mexico
Hernández B.:
UNAM, Fac Estudios Super Cuautitlan, Div Estudios Posgrad Tecnol Farmaceut, Cuautitlan 54740, Estado De Mexic, Mexico
División de Estudios de Posgrado (Tecnología Farmacéutica), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Av. Primero de Mayo S/N, Cuautitlan Izcalli. C.P. 54740, Estado de Mexico, Mexico
Ganem A.:
UNAM, Fac Estudios Super Cuautitlan, Div Estudios Posgrad Tecnol Farmaceut, Cuautitlan 54740, Estado De Mexic, Mexico
División de Estudios de Posgrado (Tecnología Farmacéutica), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Av. Primero de Mayo S/N, Cuautitlan Izcalli. C.P. 54740, Estado de Mexico, Mexico
Melgoza L.M.:
Universidad Autónoma Metropolitana - Xochimilco, Departamento de Sistemas Bioliógicos, Calzada del Hueso 1100, Delegacion Coyoacan, 04960 Mexico D.F., Mexico
Young P.M.:
Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia
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