Regional differences in the vasorelaxing effects of testosterone and its 5-reduced metabolites in the canine vasculature
Por:
Perusquía M., Espinoza J., Montano, LM, Stallone J.N.
Publicada:
1 mar 2012
Resumen:
Although the vasorelaxing effects of testosterone (T) and various androgen metabolites have been observed in a variety of blood vessels and species, previous studies have not systematically compared the vasorelaxing effects of androgen metabolites in different vascular beds within the same species. Therefore, we studied the vasorelaxing effects of T and its 5-reduced metabolites (5 alpha- and 5 beta-DHT) on KCl-induced contractions of the canine left coronary artery, femoral artery and saphenous vein, using standard isometric recordings. KCl contractions were inhibited by each androgen in a concentration-dependent manner from 1.8 to 310 mu M. Vascular sensitivity and efficacy were expressed as inhibitory concentration 50 (IC50) and maximal relaxation (R-max), respectively. The coronary artery was significantly more sensitive to androgen-induced vasorelaxation than the saphenous vein or femoral artery. These vasorelaxing responses were unaffected by an antiandrogen (Flutamide) or the su
Filiaciones:
Perusquía M.:
Departamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, 04510 México D.F., Mexico
Espinoza J.:
Departamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, 04510 México D.F., Mexico
Montano, LM:
Univ Nacl Autonoma Mexico, Fac Med, Dept Farmacol, Mexico City 04510, DF, Mexico
Stallone J.N.:
Michael E. DeBakey Institute-Women's Health Division, Texas A and M University, College Station, TX 77843-4466, United States
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