On the Nature of the Tumor-Initiating Cell
Por:
Lara-Padilla E., Cáceres-Cortés J.R.
Publicada:
1 ene 2012
Categoría:
Medicine (miscellaneous)
Resumen:
Certain aspects of tumors that may influence areas of basic biology and medicine are reviewed. The hypothesis that malignant stem cells evolve from normal stem cells, is considered. Information is being accumulated on the possibility that certain cell populations that can be propagated as cell lines in vitro can produce cells with features of differentiated cells in addition to others that maintain the line and, in some cases may also initiate tumor formation in vivo. Up to the present time, there is evidence to show that cancer stem cells persist in many cell lines. Tyrosine kinase inhibition produces combinations of autophagy and apoptosis in the human erythroleukemia cell line TF-1 hinting at a heterotypic aggregation of cells containing cancer stem cells. Finally, the mechanisms of cancer development, invasion and metastasis are operatively defined. The purpose of this paper is to review some of the salient features of cancer stem cells in support of the proposal that research in n
Filiaciones:
Lara-Padilla E.:
Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Col. Casco de Santo Tomas, Delegación Miguel Hidalgo, Plan de San Luis y Díaz Mirón s/n, C.P. México 11340, D.F., Mexico
Cáceres-Cortés J.R.:
Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Col. Casco de Santo Tomas, Delegación Miguel Hidalgo, Plan de San Luis y Díaz Mirón s/n, C.P. México 11340, D.F., Mexico
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