Genetic and antigenic changes in porcine rubulavirus
Por:
Sánchez-Betancourt J.I., Trujillo M.E., Mendoza S.E., Reyes-Leyva J., Alonso R.A.
Publicada:
1 ene 2012
Categoría:
Veterinary (miscellaneous)
Resumen:
Blue eye disease, caused by a porcine rubulavirus (PoRV), is an emergent viral swine disease that has been endemic in Mexico since 1980. Atypical outbreaks were detected in 1990 and 2003. Growing and adult pigs presented neurological signs, mild neurological signs were observed in piglets, and severe reproductive problems were observed in adults. Amino acid sequence comparisons and phylogenetic analysis of the hemagglutinin-neuraminidase (HN) protein revealed genetically different lineages. We used cross-neutralization assays, with homologous and heterologous antisera, to determine the antigenic relatedness values for the PoRV isolates. We found antigenic changes among several strains and identified a highly divergent one, making up a new serogroup. It seems that genetically and antigenically different PoRV strains are circulating simultaneously in the swine population in the geographical region studied. The cross neutralization studies suggest that the HN is not the only antigenic det
Filiaciones:
Sánchez-Betancourt J.I.:
UNAM, Fac Med Vet & Zootecnia, Dept Prod Anim Cerdos, Del Coyoacan 04510, DF, Mexico
Trujillo M.E.:
UNAM, Fac Med Vet & Zootecnia, Dept Prod Anim Cerdos, Del Coyoacan 04510, DF, Mexico
Mendoza S.E.:
UNAM, Fac Estudios Super Cuautitlan, Microbiol Lab, Del Coyoacan 04510, DF, Mexico
Reyes-Leyva J.:
Laboratorio de Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social. Km 4.5 carretera Atlixco-Metepec, Puebla, Mexico
Alonso R.A.:
UNAM, Fac Med Vet & Zootecnia, Dept Genet Bioestadist, Del Coyoacan 04510, DF, Mexico
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