Rehabilitating a brain with Alzheimer's: a proposal


Por: Aranda-Abreu G.E., Hernández-Aguilar M.E., Denes J.M., Hernandez, LIG, Rivero M.H.

Publicada: 1 ene 2011
Categoría: Geriatrics and Gerontology

Resumen:
Alzheimer's disease (AD) is the most common neurodegenerative disorder, originating sporadically in the population aged over 65 years, and advanced age is the principal risk factor leading to AD development. In spite of the large amount of research going on around the globe and all the information now available about AD, there is still no origin or triggering process known so far. Drugs approved for the treatment of AD include tacrine, donepezil, rivastigmine, galantamine, and memantine. These may delay or slow down the degenerative process for a while, but they can neither stop nor reverse its progression. Because that this might be due to a lack of effect of these drugs on degenerating neurons, even when they are able to potentiate the brain in nondegenerative conditions, we propose here an alternative therapy consisting of initial repair of neuronal membranes followed by conventional drug therapies. The rehabilitation of neurons in a degeneration process would enable the drugs to ac

Filiaciones:
Aranda-Abreu G.E.:
 Universidad Veracruzana, Av Luis Castelazo Ayala, Carretera Xalapa-Veracruz, 91190, Mexico

 Cuerpo Académico de Neuroquímica, Mexico

Hernández-Aguilar M.E.:
 Universidad Veracruzana, Av Luis Castelazo Ayala, Carretera Xalapa-Veracruz, 91190, Mexico

 Cuerpo Académico de Neuroquímica, Mexico

Denes J.M.:
 Universidad Veracruzana, Av Luis Castelazo Ayala, Carretera Xalapa-Veracruz, 91190, Mexico

 Cuerpo Académico de Neurociencias, Mexico

Rivero M.H.:
 Doctorado en Ciencias Biomédicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico
ISSN: 11781998
Editorial
DOVE MEDICAL PRESS LTD, PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND, Nueva Zelanda
Tipo de documento: Review
Volumen: 6 Número: 1
Páginas: 53-59
WOS Id: 000299337200007
ID de PubMed: 21472092
imagen Gold

MÉTRICAS