The design and inhibitory profile of new benzimidazole derivatives against triosephosphate isomerase from Trypanosoma cruzi: A problem of residue motility
Por:
Romo-Mancillasa A., Téllez-Valenciab A., Yépez-Muliac L., Hernández-Luisa F., Hernández-Camposa A., Castillo R.
Publicada:
1 sep 2011
Resumen:
To develop a new set of compounds with inhibitory activity against the triosephosphate isomerase of Trypanosoma cruzi (TcTIM), a group of benzimidazole derivatives was studied using four different docking procedures. These docking procedures differ in the number and type of mobile residues considered in the analysis. As a result of this methodology, a clustered analysis of plausible candidate structures was produced. A different set of previously synthesized compounds was used to validate this analysis. The validation showed that the best results correspond to the docking procedure in which the residues near the hydrophobic pocket of the protein's interface were considered mobile. A binding site for the best candidates was identified. Residues Tyr103, Glu105 and Lys113, among others, are important for the binding of this kind of compound. Residue Tyr103 is different in the human TIM, thus establishing a key feature for the future design of selective inhibitors. (C) 2011 Elsevier Inc. A
Filiaciones:
Romo-Mancillasa A.:
Univ Nacl Autonoma Mexico, Dept Farm, Fac Quim, Mexico City 04510, DF, Mexico
Téllez-Valenciab A.:
Facultad de Medicina, Centro de Investigaciones en Alimentos y Nutrición, Universidad Juárez del Estado de Durango, Durango 34000, Mexico
Yépez-Muliac L.:
Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, IMSS, México DF, Mexico
Hernández-Luisa F.:
Univ Nacl Autonoma Mexico, Dept Farm, Fac Quim, Mexico City 04510, DF, Mexico
Hernández-Camposa A.:
Univ Nacl Autonoma Mexico, Dept Farm, Fac Quim, Mexico City 04510, DF, Mexico
Castillo R.:
Univ Nacl Autonoma Mexico, Dept Farm, Fac Quim, Mexico City 04510, DF, Mexico
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